TABLE OF CONTENTS

A series of titanocenes containing benzodioxole groups were synthesized using 6-benzo[1,3]dioxolefulvene. The titanocenes were tested for cytotoxicity on the pigidney LLC-PK cell line. They were found to be more cytotoxic than titanocene dichloride, but significantly less cytotoxic when compared with cis-platin and previously synthesized titanocenes.

The TBTCl effects on mitotic meta- phase plates, on pollen grains and on both microtubers and adult tuber parenchymatic cells of Allium cepa, Solanun tuberosum and Solanum melongena were investigated and the concentration of TBTCl inside the treated parenchymatic cells was determined through ICP-mass spectrometry. Oxygen and chlorophyll productions were also determined.

The redox behaviour of 4-ferrocenylcatechol bound to nanocrystalline TiO₂ electrodes in aprotic solvent was investigated. At an applied potential of + 0.45 mV (vs Ag/AgCl) the ferrocenyl group oxidised to the ferrocenium cation and the catecholate group oxidized to the benzoquinone form. At 0 V, the ferrocenium group is reduced to ferrocene but benzoquinone is not reduced to catecholate and the compound desorbs from the surface. Electrochromic switching of the ferrocenyl electrochromophore on TiO₂ with aprotic electrolyte is, therefore, irreversible.

Three novel zinc(II) complexes of 4,4-dicarboxybiphenyl sulfone were successfully synthesized. All of them are composed of 1D chains, and further architectured into 3D supramolecular structures via hydrogen bonds and - interactions. Complexes 1-3 show blue emission under UV excitation.

A new interesting category of organometa-llic charge transfer complex was obtained by the doping of ferrocenyl Schiff base with Fe³⁺, Al³⁺ and Ti³⁺ salt. The room-temperature conductivity of FeCl₃-, AlCl₃- and TiCl₃-doped complexes can reach 7.53 × 10^-5, 1.37 × 10^-4 and 9.64 × 10^-5 S cm^-1, respectively, and the electrical activation energies of the complexes (which were in the range 0.09-1.54 eV) were calculated from Arrhenius polts, indicating their favourable semiconducting behaviour.

Two novel azido-derivatives of closo-dodecaborate anion with hydrophobic and hydrophilic spacers were prepared by reaction of tetrabutylammonium azide with cyclic oxonium derivatives of the closo-dodecaborate anion. The compounds prepared can be regarded as precursors of derivatives of closo-dodecaborate anion with amino group at the terminal position of a spacer or as building blocks for click chemistry, which are useful for preparation of various conjugates with targeting molecules. A concentration dependence of the ¹¹B NMR spectra of functionalized derivatives of closo-dodecaborate anion was discovered, which is of great importance for analytical purposes.

The bioaccumulation of toxic metals and MT fractions were investigated in the gill,idney, liver and muscle of carp (Cyprinus carpio L.) co-exposed to 1.0 µg ml^-1 each of Cd²⁺, Hg²⁺ and Pb²⁺ up to 10 days. The results indicate that the metal accumulation in the tissues depend on differentinds of toxic metals and different exposure time. MTs synthesis in these tissues was clearly metal-specific. MTs in the gill may be used as a bio-marker to detect the metal pollution caused by Hg and Cd.

The antifertility and antimicrobial aspects along with the spectral characterization of lead(IV) complexes are discussed. The testicular sperm density, testicular sperm morphology, sperm motility, density of cauda epididymal spermatozoa and fertility in mating trails and biochemical parameters of reproductive organs of an interesting class of biologically potent complexes on male albino rats at the dosages are examined and discussed. In addition to this the complexes were screened against a number of fungi and bacteria to assess their growth inhibiting potential.