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IEEE Transactions on Microwave Theory and Techniques
Volume 48 Number 11, November 2000

Table of Contents for this issue

Complete paper in PDF format

Microwave Treatments for Prostate Disease

Fred Sterzer, Life Fellow, IEEE Jozef Mendecki, Daniel D. Mawhinney, Life Member, IEEE Esther Friedenthal and Arnold Melman

Page 1885.

Abstract:

This paper describes three novel microwave techniques that show promise for being useful in treating diseases of the prostate. They are: microwave urethroplasty for providing immediate symptomatic relief of urinary obstructions caused by benign prostatic hyperthrophy-this technique uses microwave balloon catheters for producing biological stems in the urethra. Initial results obtained in an Federal Drug Administration approved Phase I clinical trial are highly encouraging, hyperthermia produced in the prostate by dual microwave balloon catheters-when combined with external beam radiation or implanted radioactive seeds, this technique has the potential of improving local recurrence rates of prostate cancer over the rates that are obtained when only radiation treatments are given, and microwave poration therapy-a therapy that,when combined with either systemic or locally administered chemotherapy, has been shown to be effective in shrinking implanted prostatic tumors in rats. The potential clinical advantages of microwave poration/chemotherapy over electrochemotherapy using dc pulses for treating cancers are discussed.

References

  1. F. Sterzer, "Localized heating of deep-seated tissues using microwave balloon catheters,"in New Frontiers in Medical Device Technology , A. Rosen, and H. D. Rosen, Ed. New York: Wiley, 1995, ch. 4.
  2. F. Sterzer, "Catheters for treating prostate disease", U.S. Patent 5 007 437, Apr. 16, 1991.
  3. M. S. Ernstoff et al., Prostate Cancer, Oxford: U.K.: Blackwell, 1998, ch. 2.
  4. J. Overgaard et al., "Hyperthermia as an adjuvant to radiation therapy of recurrent or metastatic malignant melanoma. A multicenter randomized trial by the European Society for Hyperthermic Oncology", Int. J. Hyperthermia, vol. 12, no. 1, pp.  3-30, 1996.
  5. R. J. Myerson, "A phase I/II study to evaluate radiation therapy and hyperthermia for deep-seated tumors: A report to RTOG 89-08", Int. J. Hyperthermia, vol. 12, no. 4, pp.  449-459, 1996.
  6. J. Mendecki, E. Friedenthal, C. Botstein, R. Paglione and F. Sterzer, "Microwave applicators for localized hyperthermia treatment of cancer of the prostate", Int. J. Radiat. Oncol. , vol. 6, pp.  1583-1588, Nov.  1980.
  7. F. Sterzer and R. W. Paglione, "Nonsymmetrical bulb applicator for hyperthermic treatment of the body", U.S. Patent 4 311 154, Jan. 19, 1982.
  8. R. Paglione, F. Sterzer, J. Mendecki, E. Friedenthal and C. Botstein, "27 MHz ridged waveguide applicators for localized hyperthermia treatment of deep-seated malignant tumors", Microwave J., pp.  71-80, February  1981.
  9. M. S. Anscher et al., "Combined external beam irradiation and external regional hyperthermia for locally advanced adenocarcinoma of the prostate", Int. J. Radiat. Oncol., pp.  1059-65, Mar.  1997 .
  10. J. C. Weaver and Y. Chizmadzhev, "Electroporation,"in Handbook of Biological Effects of Electromagnetic Fields, 2nd ed.   C. Polk, and E. Postow, Eds. Boca Raton, FL: CRC Press, 1996, pp.  247-274. 
  11. L. M. Mir et al., "Electrochemotherapy potentiation of antitumor effect of bleomycin by local electric pulses", European J. Cancer, vol. 27, pp.  68-72, 1991 .
  12. C. Domenge et al., "Antitumor electrochemotherapy: New advances in the clinical protocol", Cancer, vol. 77, no. 5, pp.  956-63, Mar.  1, 1996.
  13. L. F. Glass et al., "Bleomycin-mediated electrochemotherapy of metastatic melanoma", Arch. Dermatol., vol. 132, pp.  1353-1357, Nov.  1996.
  14. F. Sterzer, "Method for enhancing delivery of chemotherapy employing high-frequency force fields", U.S. Patent 5 386 837, Feb. 7, 1995.
  15. Y. Okada, Cell Fusion and Cell Technology, Tokyo: Japan: Kodansha, 1979, p.  4. 
  16. A. S. Gilmour, Jr., Microwaves Tubes, Norwood, MA: Artech House, 1986, ch. 15.