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PERSPECTIVES
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3743-3778
| Mixture-Based Synthetic Combinatorial Libraries
Richard A. Houghten,
Clemencia Pinilla,
Jon R. Appel,
Sylvie E. Blondelle,
Colette T. Dooley,
Jutta Eichler,
Adel Nefzi, and
John M. Ostresh
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COMMUNICATIONS
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3779-3784
| N-Arylpiperazinone Inhibitors of Farnesyltransferase: Discovery and Biological Activity
Theresa M. Williams,
Jeffrey M. Bergman,
Karen Brashear,
Michael J. Breslin,
Christopher J. Dinsmore,
John H. Hutchinson,
Suzanne C. MacTough,
Craig A. Stump,
Donna D. Wei,
C. Blair Zartman,
Michael J. Bogusky,
J. Christopher Culberson,
Carolyn Buser-Doepner,
Joseph Davide,
Ian B. Greenberg,
Kelly A. Hamilton,
Kenneth S. Koblan,
Nancy E. Kohl,
Dongming Liu,
Robert B. Lobell,
Scott D. Mosser,
Timothy J. O'Neill,
Elaine Rands,
Michael D. Schaber,
Francine Wilson,
Edith Senderak,
Sherri L. Motzel,
Jackson B. Gibbs,
Samuel L. Graham,
David C. Heimbrook,
George D. Hartman,
Allen I. Oliff, and
Joel R. Huff
[Full Article -
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3785-3788
A Ureido-Thioisobutyric Acid (GW9578) Is a Subtype-Selective PPAR Agonist with Potent Lipid-Lowering Activity
Peter J. Brown,
Deborah A. Winegar,
Kelli D. Plunket,
Linda B. Moore,
Michael C. Lewis,
Joan G. Wilson,
Scott S. Sundseth,
Cecilia S. Koble,
Zhengdong Wu,
James M. Chapman,
Jürgen M. Lehmann,
Steven A. Kliewer, and
Timothy M. Willson
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EXPEDITED ARTICLES
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3789-3799
| Discovery of Novel Antitumor Sulfonamides Targeting G1 Phase of the Cell Cycle
Takashi Owa,
Hiroshi Yoshino,
Tatsuo Okauchi,
Kentaro Yoshimatsu,
Yoichi Ozawa,
Naoko Hata Sugi,
Takeshi Nagasu,
Nozomu Koyanagi, and
Kyosuke Kitoh
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3800-3808
| Novel Farnesol and Geranylgeraniol Analogues: A Potential New Class of Anticancer Agents Directed against Protein Prenylation
Barbara S. Gibbs,
Todd J. Zahn,
YongQi Mu,
Judith S. Sebolt-Leopold, and
Richard A. Gibbs
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ARTICLES
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3809-3820
| Design and Synthesis of Potent Non-Polyglutamatable Quinazoline Antifolate Thymidylate Synthase Inhibitors
Peter R. Marsham,
J. Michael Wardleworth,
F. Thomas Boyle,
Laurent F. Hennequin,
Rosemary Kimbell,
Melody Brown, and
Ann L. Jackman
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3821-3834
| Occluded Molecular Surface Analysis of Ligand-Macromolecule Contacts: Application to HIV-1 Protease-Inhibitor Complexes
Nagarajan Pattabiraman
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3835-3844
| Design and Fast Synthesis of C-Terminal Duplicated Potent C2-Symmetric P1/P1'-Modified HIV-1 Protease Inhibitors
Mathias Alterman,
Hans O. Andersson,
Neeraj Garg,
Göran Ahlsén,
Seved Lövgren,
Björn Classon,
U. Helena Danielson,
Ingmar Kvarnström,
Lotta Vrang,
Torsten Unge,
Bertil Samuelsson, and
Anders Hallberg
[Full Article -
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3845-3851
| Crystallographic Analysis of the Binding Modes of Thiazoloisoindolinone Non-Nucleoside Inhibitors to HIV-1 Reverse Transcriptase and Comparison with Modeling Studies
Jingshan Ren,
Robert M. Esnouf,
Andrew L. Hopkins,
David I. Stuart, and
David K. Stammers
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3852-3859
| Novel Inhibitors of Erm Methyltransferases from NMR and Parallel Synthesis
Philip J. Hajduk,
Jürgen Dinges,
Jeffrey M. Schkeryantz,
David Janowick,
Michele Kaminski,
Michael Tufano,
David J. Augeri,
Andrew Petros,
Vicki Nienaber,
Ping Zhong,
Rachel Hammond,
Michael Coen,
Bruce Beutel,
Leonard Katz, and
Stephen W. Fesik
[Full Article -
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3860-3873
| Substituted Isoquinolines and Quinazolines as Potential Antiinflammatory Agents. Synthesis and Biological Evaluation of Inhibitors of Tumor Necrosis Factor
Qi Chao,
Lynn Deng,
Hsiencheng Shih,
Lorenzo M. Leoni,
Davide Genini,
Dennis A. Carson, and
Howard B. Cottam
[Full Article -
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3874-3888
| Synthesis, Pharmacological and Biophysical Characterization, and Membrane-Interaction QSAR Analysis of Cationic Amphiphilic Model Compounds
Christian D. P. Klein,
Martin Klingmüller,
Christiane Schellinski,
Silke Landmann,
Stefanie Hauschild,
Dieter Heber,
Klaus Mohr, and
A. J. Hopfinger
[Full Article -
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3889-3898
A Combinatorial Approach to the Identification of Dipeptide Aldehyde Inhibitors of  -Amyloid Production
Jeffrey N. Higaki,
Sarvajit Chakravarty,
Carmen M. Bryant,
Lisa R. Cowart,
Paul Harden,
Jan Marian Scardina,
Babu Mavunkel,
Gregory R. Luedtke, and
Barbara Cordell
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3899-3909
| Glycosylation of Fluoroquinolones through Direct and Oxygenated Polymethylene Linkages as a Sugar-Mediated Active Transport System for Antimicrobials
Michael E. Jung,
Eric C. Yang,
Binh T. Vu,
Mehrak Kiankarimi,
Emmanouil Spyrou, and
Jon Kaunitz
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3910-3918
| Conformations of Trypsin-Bound Amidine Inhibitors of Blood Coagulant Factor Xa by Double REDOR NMR and MD Simulations
Lynda M. McDowell,
Margaret A. McCarrick,
Daniel R. Studelska,
William J. Guilford,
Damian Arnaiz,
Jerry L. Dallas,
David R. Light,
Marc Whitlow, and
Jacob Schaefer
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3919-3933
| Prospective Identification of Biologically Active Structures by Topomer Shape Similarity Searching
Richard D. Cramer,
Michael A. Poss,
Mark A. Hermsmeier,
Thomas J. Caulfield,
Mark C. Kowala, and
Maria T. Valentine
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3934-3941
| Novel 2-Phenylimidazo[1,2-a]pyridine Derivatives as Potent and Selective Ligands for Peripheral Benzodiazepine Receptors: Synthesis, Binding Affinity, and in Vivo Studies
Giuseppe Trapani,
Massimo Franco,
Andrea Latrofa,
.Laura Ricciardi,
Angelo Carotti,
Mariangela Serra,
Enrico Sanna,
Giovanni Biggio, and
Gaetano Liso
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3942-3952
| 2,4,6-Triarylchalcogenopyrylium Dyes Related in Structure to the Antitumor Agent AA1 as in Vitro Sensitizers for the Photodynamic Therapy of Cancer
Kristi A. Leonard,
Marina I. Nelen,
Linda T. Anderson,
Scott L. Gibson,
Russell Hilf, and
Michael R. Detty
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3953-3964
| Synthesis and Evaluation of Chalcogenopyrylium Dyes as Potential Sensitizers for the Photodynamic Therapy of Cancer
Kristi A. Leonard,
Marina I. Nelen,
Todd P. Simard,
Sherry R. Davies,
Sandra O. Gollnick,
Allan R. Oseroff,
Scott L. Gibson,
Russell Hilf,
Lan Bo Chen, and
Michael R. Detty
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3965-3970
Synthesis and SAR of 1-Alkyl-2-phenylethylamine Derivatives Designed from N,N-Dipropyl-4-methoxy-3-(2-phenylethoxy)phenylethylamine To Discover  1 Ligands
Atsuro Nakazato,
Toshihito Kumagai,
Kohmei Ohta,
Shigeyuki Chaki,
Shigeru Okuyama, and
Kazuyuki Tomisawa
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3971-3981
| Synthesis and Structure-Activity Relationships of Phenylenebis(methylene)- Linked Bis-azamacrocycles That Inhibit HIV-1 and HIV-2 Replication by Antagonism of the Chemokine Receptor CXCR4
Gary J. Bridger,
Renato T. Skerlj,
Sreenivasan Padmanabhan,
Stephen A. Martellucci,
Geoffrey W. Henson,
Sofie Struyf,
Myriam Witvrouw,
Dominique Schols, and
Erik De Clercq
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3982-3993
| Axially Chiral 1,7-Naphthyridine-6-carboxamide Derivatives as Orally Active Tachykinin NK1 Receptor Antagonists: Synthesis, Antagonistic Activity, and Effects on Bladder Functions
Hideaki Natsugari,
Yoshinori Ikeura,
Izumi Kamo,
Takenori Ishimaru,
Yuji Ishichi,
Akira Fujishima,
Toshimasa Tanaka,
Fumiko Kasahara,
Mitsuru Kawada, and
Takayuki Doi
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3994-4000
| Prodrugs for Amidines: Synthesis and Anti-Pneumocystis carinii Activity of Carbamates of 2,5-Bis(4-amidinophenyl)furan
Syed M. Rahmathullah,
James Edwin Hall,
Brendan C. Bender,
Donald R. McCurdy,
Richard R. Tidwell, and
David W. Boykin
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4001-4009
| Combinatorial Library of Serine and Cysteine Protease Inhibitors That Interact with Both the S and S' Binding Sites
Paul Abato,
Jeffrey L. Conroy, and
Christopher T. Seto
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BRIEF ARTICLES
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4010-4013
| Novel Lipoamino Acid- and Liposaccharide-Based System for Peptide Delivery: Application for Oral Administration of Tumor-Selective Somatostatin Analogues
István Tóth,
John P. Malkinson,
Nicholas S. Flinn,
Bruno Drouillat,
Anikó Horváth,
Judith Érchegyi,
Miklós Idei,
Anikó Venetianer,
Per Artursson,
Lucia Lazorova,
Béla Szende, and
György Kéri
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ADDITIONS AND CORRECTIONS
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4014-4014
| Non-Peptide GPIIb/IIIa Inhibitors. 20. Centrally Constrained Thienothiophene -Sulfonamides Are Potent, Long Acting in Vivo Inhibitors of Platelet Aggregation
Melissa S. Egbertson,
Jacquelynn J. Cook,
Bohumil Bednar,
John D. Prugh,
Rodney A. Bednar,
Stanley L. Gaul,
Robert J. Gould,
George D. Hartman,
Carl F. Homnick,
Marie A. Holahan,
Laura A. Libby,
Joseph J. Lynch, Jr.,Robert J.
Lynch,
Gary R. Sitko,
Maria T. Stranieri, and
Laura M. Vasallo
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