139-141
Structural Determinants of Efficacy for 
Opioid Receptors in the Orvinol Series: 7,7-Spiro Analogues of Buprenorphine
142-145
Synthesis and Pharmacological Characterization of [125I]Iodomethyllycaconitine ([125I]Iodo-MLA). A New Ligand for the 
7 Nicotinic Acetylcholine Receptor
EXPEDITED ARTICLES
146-155
Structure-Based Discovery of Small Molecule Inhibitors Targeted to Protein Tyrosine Phosphatase 1B
ARTICLES
156-166
Structure-Activity Relationships and Pharmacokinetic Analysis for a Series of Potent, Systemically Available Biphenylsulfonamide Matrix Metalloproteinase Inhibitors
167-176
Antitumor Agents. 199. Three-Dimensional Quantitative Structure-Activity Relationship Study of the Colchicine Binding Site Ligands Using Comparative Molecular Field Analysis
177-189
3,4-Dihydro-2(1H)-quinolinone as a Novel Antidepressant Drug: Synthesis and Pharmacology of 1-[3-[4-(3-Chlorophenyl)-1-piperazinyl]propyl]-3,4- dihydro-5-methoxy-2(1H)-quinolinone and Its Derivatives
190-198
A Potential Melanoma Tracer: Synthesis, Radiolabeling, and Biodistribution in Mice of a New Nitridotechnetium Bis(aminothiol) Derivative Pharmacomodulated by a N-(Diethylaminoethyl)benzamide
199-204
Synthesis and in Vitro Anti-Mycobacterium Activity of N-Alkyl-1,2-dihydro-2-thioxo-3-pyridinecarbothioamides. Preliminary Toxicity and Pharmacokinetic Evaluation
205-213
Novel 3-Aminomethyl- and 4-Aminopiperidine Analogues of 1-[2-(Diphenylmethoxy)ethyl]-4-(3-phenylpropyl)piperazines: Synthesis and Evaluation as Dopamine Transporter Ligands
214-223
Synthesis and Biological Evaluation of 3,4-Diaryloxazolones: A New Class of Orally Active Cyclooxygenase-2 Inhibitors
224-235
Synthesis and Evaluation of Hydroxylated Polyamine Analogues as Antiproliferatives
236-249
Secondary Amides of (R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase
250-260
N-Cycloalkyl Derivatives of Adenosine and 1-Deazaadenosine as Agonists and Partial Agonists of the A1 Adenosine Receptor
261-269
Esterase-Sensitive Nitric Oxide Donors of the Diazeniumdiolate Family: In Vitro Antileukemic Activity
270-277
A Structure-Affinity Relationship Study on Derivatives of N-[2-[4-(4-Chlorophenyl)piperazin-1-yl]ethyl]-3-methoxybenzamide, a High-Affinity and Selective D4 Receptor Ligand
278-282
Synthesis and Antiviral Activity of Novel Anti-VZV 5-Substituted Uracil Nucleosides with a Cyclopropane Sugar Moiety
283-291
Structure-Function Relationships in Aminoquinolines: Effect of Amino and Chloro Groups on Quinoline-Hematin Complex Formation, Inhibition of 
-Hematin Formation, and Antiplasmodial Activity
292-300
Carbonic Anhydrase Inhibitors: Synthesis of Membrane-Impermeant Low Molecular Weight Sulfonamides Possessing in Vivo Selectivity for the Membrane-Bound versus Cytosolic Isozymes
BOOK REVIEWS
301-301
Organic Reactions. Volume 54 Leo A. Paquette, Editor-in-Chief. John Wiley & Sons, Inc., New York. 1999. vii + 442 pp. 16 × 24 cm. ISBN 0-471-34888-0. $89.95.
302-302
Molecular Structure Description. The Electrotopological State By Lemont B. Kier and Lowell H. Hall. Forward by Gerald M. Maggiora. Academic Press, San Diego, CA. 1999. xx + 245 + 41 pp. 16 x 35 cm. ISBN 0-12-406555-4. $99.95.
ADDITIONS AND CORRECTIONS
303-303
Synthesis, Structure-Activity Relationships, and RAR 
-Ligand Interactions of Nitrogen Heteroarotinoids.
304-304
Urea-PETT Compounds as a New Class of HIV-1 Reverse Transcriptase Inhibitors. 3. Synthesis and Further Structure-Activity Relationship Studies of PETT Analogues.