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PERSPECTIVES
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305-341
| Protease Inhibitors: Current Status and Future Prospects
Donmienne Leung,
Giovanni Abbenante, and
David P. Fairlie
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COMMUNICATIONS
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342-345
A Novel, Potent, and Selective 5-HT7 Antagonist: (R)-3-(2-(2-(4-Methylpiperidin-1-yl)ethyl)pyrrolidine-1-sulfonyl)phenol (SB-269970)
Peter J. Lovell,
Steven M. Bromidge,
Steven Dabbs,
D. Malcolm Duckworth,
Ian T. Forbes,
Andrew J. Jennings,
Frank D. King,
Derek N. Middlemiss,
Shirley K. Rahman,
Damian V. Saunders,
Lissa L. Collin,
Jim J. Hagan,
Graham J. Riley, and
David R. Thomas
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346-350
 -Substituted N-(Sulfonamido)alkyl- -aminotetralins: Potent and Selective Neuropeptide Y Y5 Receptor Antagonists
Mark A. Youngman,
James J. McNally,
Timothy W. Lovenberg,
Allen B. Reitz,
Nicole M. Willard,
Diane H. Nepomuceno,
Sandy J. Wilson,
Jeffrey J. Crooke,
Daniel Rosenthal,
Anil H. Vaidya, and
Scott L. Dax
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EXPEDITED ARTICLES
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351-360
Discovery of a Novel Dopamine Transporter Inhibitor, 4-Hydroxy-1-methyl-4-(4-methylphenyl)-3-piperidyl 4-Methylphenyl Ketone, as a Potential Cocaine Antagonist through 3D-Database Pharmacophore Searching. Molecular Modeling, Structure-Activity Relationships, and Behavioral Pharmacological Studies
Shaomeng Wang,
Sukumar Sakamuri,
Istvan J. Enyedy,
Alan P. Kozikowski,
Olivier Deschaux,
Bidhan C. Bandyopadhyay,
Srihari R. Tella,
Wahiduz A. Zaman, and
Kenneth M. Johnson
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ARTICLES
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361-368
Structural Basis of the Thrombin Selectivity of a Ligand That Contains the Constrained Arginine Mimic (2S)-2-Amino-(3S)-3-(1-carbamimidoyl- piperidin-3-yl)-propanoic Acid at P1
Lakshmi S. Narasimhan,
J. Ronald Rubin,
Debra R. Holland,
Janet S. Plummer,
Stephen T. Rapundalo,
Jeremy E. Edmunds,
Yves St-Denis,
M. Arshad Siddiqui, and
Christine Humblet
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369-380
Design and Synthesis of Piperazine-Based Matrix Metalloproteinase Inhibitors
Menyan Cheng,
Biswanath De,
Stanislaw Pikul,
Neil G. Almstead,
Michael G. Natchus,
Melanie V. Anastasio,
Sara J. McPhail,
Catherine E. Snider,
Yetunde O. Taiwo,
Longyin Chen,
C. Michelle Dunaway,
Fei Gu,
Martin E. Dowty,
Glen E. Mieling,
Michael J. Janusz, and
Sherry Wang-Weigand
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381-391
Molecular Docking Reveals a Novel Binding Site Model for Fentanyl at the  -Opioid Receptor
Govindan Subramanian,
M. Germana Paterlini,
Philip S. Portoghese, and
David M. Ferguson
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392-400
Derivation of Pharmacophore and CoMFA Models for Leukotriene D4 Receptor Antagonists of the Quinolinyl(bridged)aryl Series
Albert Palomer,
Jaume Pascual,
Francesc Cabré,
M. Lluïsa García, and
David Mauleón
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401-408
Successful Virtual Screening of a Chemical Database for Farnesyltransferase Inhibitor Leads
Emanuele Perola,
Kun Xu,
Thomas M. Kollmeyer,
Scott H. Kaufmann,
Franklyn G. Prendergast, and
Yuan-Ping Pang
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409-419
Syntheses and Structure-Activity Relationships of 5,6,7,8-Tetrahydro-5,5,8,8-tetramethyl-2-quinoxaline Derivatives with Retinoic Acid Receptor Agonistic Activity
Kouichi Kikuchi,
Shigeki Hibi,
Hiroyuki Yoshimura,
Naoki Tokuhara,
Kenji Tai,
Takayuki Hida,
Toshihiko Yamauchi, and
Mitsuo Nagai
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420-431
Synthesis, Molecular Modeling, and Pharmacological Testing of Bis-Quinolinium Cyclophanes: Potent, Non-Peptidic Blockers of the Apamin-Sensitive Ca2+-Activated K+ Channel
Joaquin Campos Rosa,
Dimitrios Galanakis,
Alessandro Piergentili,
Kalpana Bhandari,
C. Robin Ganellin,
Philip M. Dunn, and
Donald H. Jenkinson
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432-439
Synthesis and in Vitro and in Vivo Functional Studies of Ortho-Substituted Phenylpiperazine and N-Substituted 4-N-(o-Methoxyphenyl)aminopiperidine Analogues of WAY100635
Marguérite M. Mensonides-Harsema,
Yi Liao,
Henning Böttcher,
Gerd D. Bartoszyk,
Hartmunt E. Greiner,
Jürgen Harting,
Peter de Boer, and
Håkan V. Wikström
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440-448
Water-Soluble Phosphate Prodrugs of 1-Propargyl-8-styrylxanthine Derivatives, A2A-Selective Adenosine Receptor Antagonists
Roland Sauer,
Juris Maurinsh,
Ulrike Reith,
Friederike Fülle,
Karl-Norbert Klotz, and
Christa E. Müller
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449-456
4-(1,3-Dimethoxyprop-2-ylamino)-2,7-dimethyl-8-(2,4-dichlorophenyl)pyrazolo[1,5-a]-1,3,5-triazine: A Potent, Orally Bioavailable CRF1 Receptor Antagonist
Liqi He,
Paul J. Gilligan,
Robert Zaczek,
Lawrence W. Fitzgerald,
John McElroy,
H-S. L. Shen,
Jo Anne Saye,
Ned H. Kalin,
Steven Shelton,
David Christ,
George Trainor, and
Paul Hartig
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457-466
Design of Cancer-Specific Antitumor Agents Based on Aziridinylcyclopent[b]indoloquinones
Chengguo Xing,
Ping Wu, and
Edward B. Skibo
, Robert T. Dorr
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467-474
Acid-Catalyzed Degradation of Clarithromycin and Erythromycin B: A Comparative Study Using NMR Spectroscopy
Mohd N. Mordi,
Michelle D. Pelta,
Valerie Boote,
Gareth A. Morris, and
Jill Barber
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475-487
Drug Delivery Systems Based on Trimethyl Lock Lactonization: Poly(ethylene glycol) Prodrugs of Amino-Containing Compounds
Richard B. Greenwald,
Yun H. Choe,
Charles D. Conover,
Kwok Shum,
Dechun Wu, and
Maksim Royzen
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488-504
Potent and Selective Non-Peptidic Inhibitors of Endothelin-Converting Enzyme-1 with Sustained Duration of Action
Stéphane De Lombaert,
Louis Blanchard,
Lisa B. Stamford,
Jenny Tan,
Eli M. Wallace,
Yoshitaka Satoh,
John Fitt,
Denton Hoyer,
David Simonsbergen,
John Moliterni,
Nicholas Marcopoulos,
Paula Savage,
Mary Chou,
Angelo J. Trapani, and
Arco Y. Jeng
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505-516
Antimalarial Activity of Compounds Interfering with Plasmodium falciparum Phospholipid Metabolism: Comparison between Mono- and Bisquaternary Ammonium Salts
Michèle Calas,
Marie L. Ancelin,
Gérard Cordina,
Philippe Portefaix,
Gilles Piquet,
Valérie Vidal-Sailhan, and
Henri Vial
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BRIEF ARTICLES
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517-525
New Selective and Potent 5-HT1B/1D Antagonists: Chemistry and Pharmacological Evaluation of N-Piperazinylphenyl Biphenylcarboxamides and Biphenylsulfonamides
Yi Liao,
Henning Böttcher,
Jürgen Harting,
Hartmut Greiner,
Christoph van Amsterdam,
Thomas Cremers,
Staffan Sundell,
Joachim März,
Wilfried Rautenberg, and
Håkan Wikström
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BOOK REVIEWS
|
526-526
| Process Chemistry in the Pharmaceutical Industry Edited by Kumar Gadamasetti. Marcel Dekker, Inc., New York. 1999. xii + 474 pp. 18 × 26 cm. ISBN 0-8247-1981-6. $195.00.
Vance Novack
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