1641-1660
Corticotropin Releasing Factor (CRF) Receptor Modulators: Progress and Opportunities for New Therapeutic Agents
COMMUNICATIONS
1661-1663
N-[[(5-Methyl-3-phenylisoxazol-4-yl)- phenyl]sulfonyl]propanamide, Sodium Salt, Parecoxib Sodium: A Potent and Selective Inhibitor of COX-2 for Parenteral Administration
EXPEDITED ARTICLES
1664-1669
Potent Derivatives of Glucagon-like Peptide-1 with Pharmacokinetic Properties Suitable for Once Daily Administration
gersen,
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ARTICLES
1670-1683
Substituted Benzamide Inhibitors of Human Rhinovirus 3C Protease: Structure-Based Design, Synthesis, and Biological Evaluation
1684-1691
Molecular Determinants of MAO Selectivity in a Series of Indolylmethylamine Derivatives: Biological Activities, 3D-QSAR/CoMFA Analysis, and Computational Simulation of Ligand Recognition
1692-1698
Probing the Conformation of the Sugar Transport Inhibitor Phlorizin by 2D-NMR, Molecular Dynamics Studies, and Pharmacophore Analysis
1699-1704
2-Amino-2-oxazolines as Subtype Selective 
2 Adrenoceptor Agonists
1705-1713
New Proline Mimetics: Synthesis of Thrombin Inhibitors Incorporating Cyclopentane- and Cyclopentenedicarboxylic Acid Templates in the P2 Position. Binding Conformation Investigated by X-ray Crystallography
1714-1722
Design and Synthesis of Conformationally Constrained Glucagon Analogues
1723-1740
Toward General Methods of Targeted Library Design: Topomer Shape Similarity Searching with Diverse Structures as Queries
1741-1753
Solution Structures in SDS Micelles and Functional Activity at the Bullfrog Substance P Receptor of Ranatachykinin Peptides
1754-1761
Characterization of the Binding Site of the Histamine H3 Receptor. 2. Synthesis, in Vitro Pharmacology, and QSAR of a Series of Monosubstituted Benzyl Analogues of Thioperamide
1762-1769
Screening of New Antioxidant Molecules Using Flow Cytometry
1770-1779
Design of a Gag Pentapeptide Analogue that Binds Human Cyclophilin A More Efficiently than the Entire Capsid Protein: New Insights for the Development of Novel Anti-HIV-1 Drugs
1780-1792
Nuclear Receptor-DNA Binding Specificity: A COMBINE and Free-Wilson QSAR Analysis
1793-1806
Protease Inhibitors: Synthesis and QSAR Study of Novel Classes of Nonbasic Thrombin Inhibitors Incorporating Sulfonylguanidine and O-Methylsulfonylisourea Moieties at P1
1807-1816
Multivariate Data Analysis Using D-Optimal Designs, Partial Least Squares, and Response Surface Modeling: A Directional Approach for the Analysis of Farnesyltransferase Inhibitors
1817-1825
Synthesis and Cytostatic Activity of Substituted 6-Phenylpurine Bases and Nucleosides: Application of the Suzuki-Miyaura Cross-Coupling Reactions of 6-Chloropurine Derivatives with Phenylboronic Acids
,
áková
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1826-1840
Design and Synthesis of Aryloxyethyl Thiocyanate Derivatives as Potent Inhibitors of Trypanosoma cruzi Proliferation
1841-1851
1-Imidazolyl(alkyl)-Substituted Di- and Tetrahydroquinolines and Analogues: Syntheses and Evaluation of Dual Inhibitors of Thromboxane A2 Synthase and Aromatase
1852-1857
Structural Determinants of Opioid Activity in the Orvinols and Related Structures: Ethers of Orvinol and Isoorvinol
1858-1865
Protease Inhibitors: Synthesis of Potent Bacterial Collagenase and Matrix Metalloproteinase Inhibitors Incorporating N-4-Nitrobenzylsulfonylglycine Hydroxamate Moieties
1866-1877
Novel Synthetic Oleanane and Ursane Triterpenoids with Various Enone Functionalities in Ring A as Inhibitors of Nitric Oxide Production in Mouse Macrophages
1878-1885
Design and Synthesis of trans-N-[4-[2-(6-Cyano-1,2,3,4-tetrahydroisoquinolin-2- yl)ethyl]cyclohexyl]-4-quinolinecarboxamide (SB-277011): A Potent and Selective Dopamine D3 Receptor Antagonist with High Oral Bioavailability and CNS Penetration in the Rat
BRIEF ARTICLES
1886-1891
Structure-Based Design, Synthesis, and Biological Evaluation of Novel Pyrrolyl Aryl Sulfones: HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors Active at Nanomolar Concentrations
1892-1897
Subtype-Selective N-Methyl-D-aspartate Receptor Antagonists: Benzimidazalone and Hydantoin as Phenol Replacements
BOOK REVIEWS
1898-1898
Handbook of Drug Metabolism Edited by Thomas L. Woolf. Marcel Dekker, New York. 1999. xi + 596 pp. 18 x 26 cm. ISBN 0-8247-0229-8. $225.00.
1898-1899
Handbook of Reagents for Organic Synthesis. Reagents, Auxiliaries, and Catalysts for C-C Bond Formation Edited by Robert M. Coates and Scott E. Denmark. John Wiley & Sons, Inc., New York. 1999. xvi + 746 pp. 22 x 28.5 cm. ISBN 0-471-97924. $115.00. Acidic and Basic Reagents. Edited by Hans J. Reich and James H. Rigby. John Wiley & Sons, Inc., New York. 1999. xii + 494 pp. 22 x 28.5 cm. ISBN 0-471-97925. $115.00. Oxidizing and Reducing Reagents. Edited by Steven D. Burke and Rick L. Danheiser. John Wiley & Sons, Inc., New York. 1999. xviii + 550 pp. 22 x 28.5 cm. ISBN 0-471-97926-0. $115.00. Activating Agents and Protecting Groups. Edited by Anthony J. Pearson and William R. Roush. John Wiley & Sons, Inc., New York. 1999. xvii + 513 pp. 22 x 28.5 cm. ISBN 0-471-97927-9. $115.00.
1899-1900
Pharmaceutical Innovation. Revolutionizing Human Health Edited by Ralph Landau, Basil Achilladelis, and Alexander Scriabine. Chemical Heritage Press, Philadelphia. 1999. xxiii + 408 pp. 16 × 24 cm. ISBN 0-941901-21-1. $44.95.