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COMMUNICATIONS
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2083-2086
SPR Biosensor Studies of the Direct Interaction between 27 Drugs and a Liposome Surface: Correlation with Fraction Absorbed in Humans
Ernest Danelian,
Anders Karlén,
Robert Karlsson,
Susanne Winiwarter,
Anna Hansson,
Stefan Löfås,
Hans Lennernäs, and
Markku D. Hämäläinen
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2087-2092
Non-Amidine-Containing 1,2-Dibenzamidobenzene Inhibitors of Human Factor Xa with Potent Anticoagulant and Antithrombotic Activity
John J. Masters,
Jeffry B. Franciskovich,
Jennifer M. Tinsley,
Charles Campbell,
Jack B. Campbell,
Trelia J. Craft,
Larry L. Froelich,
Donetta S. Gifford-Moore,
Lynne A. Hay,
David K. Herron,
Valentine J. Klimkowski,
Kenneth D. Kurz,
James T. Metz,
Andrew M. Ratz,
Robert T. Shuman,
Gerald F. Smith,
Tommy Smith,
Richard D. Towner,
Michael R. Wiley,
Alex Wilson, and
Ying K. Yee
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ARTICLES
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2093-2099
Mapping the Active Site of Angiotensin-Converting Enzyme by Transferred NOE Spectroscopy
Moriz Mayer and
Bernd Meyer
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2100-2114
Developing a Dynamic Pharmacophore Model for HIV-1 Integrase
Heather A. Carlson,
Kevin M. Masukawa,
Kathleen Rubins,
Fredric D. Bushman,
William L. Jorgensen,
Roberto D. Lins,
James M. Briggs, and
J. Andrew McCammon
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2115-2123
Synthesis, Molecular Modeling, and Opioid Receptor Affinity of 9,10-Diazatricyclo[4.2.1.12,5]decanes and 2,7-Diazatricyclo[4.4.0.03,8]decanes Structurally Related to 3,8-Diazabicyclo[3.2.1]octanes
Paola Vianello,
Alberto Albinati,
Gerardo A. Pinna,
Antonio Lavecchia,
Luciana Marinelli,
Pier Andrea Borea,
Stefania Gessi,
Paola Fadda,
Silvia Tronci, and
Giorgio Cignarella
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2124-2134
Modeling of  -Opioid Receptor/Agonists Interactions Using Pharmacophore-Based and Docking Simulations
Antonio Lavecchia,
Giovanni Greco,
Ettore Novellino,
Franco Vittorio, and
Giuseppe Ronsisvalle
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2135-2148
Peptide and Peptide Mimetic Inhibitors of Antigen Presentation by HLA-DR Class II MHC Molecules. Design, Structure-Activity Relationships, and X-ray Crystal Structures
David R. Bolin,
Amy L. Swain,
Ramakanth Sarabu,
Steven J. Berthel,
Paul Gillespie,
Nicholas J. S. Huby,
Raymond Makofske,
Lucja Orzechowski,
Agostino Perrotta,
Katherine Toth,
Joel P. Cooper,
Nan Jiang,
Fiorenza Falcioni,
Robert Campbell,
Donald Cox,
Diana Gaizband,
Charles J. Belunis,
Damir Vidovic,
Kouichi Ito,
Robert Crowther,
Ursula Kammlott,
Xiaolei Zhang,
Robert Palermo,
David Weber,
Jeanmarie Guenot,
Zoltan Nagy, and
Gary L. Olson
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2149-2154
Structure-Activity Relationships in Platelet-Activating Factor (PAF). 10. From PAF Antagonism to Inhibition of HIV-1 Replication
Nawal Serradji,
Okkacha Bensaid,
Marc Martin,
Erwan Kan,
Nathalie Dereuddre-Bosquet,
Catherine Redeuilh,
Jack Huet,
Françoise Heymans,
Aazdine Lamouri,
Pascal Clayette,
Chang Zhi Dong,
Dominique Dormont, and
Jean-Jacques Godfroid
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2155-2164
Structure-Activity Relationships in a Series of Bisquaternary Bisphthalimidine Derivatives Modulating the Muscarinic M2-Receptor Allosterically
Hector M. Botero Cid,
Christian Tränkle,
Knut Baumann,
Rainer Pick,
Elisabeth Mies-Klomfass,
Evi Kostenis,
Klaus Mohr, and
Ulrike Holzgrabe
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2165-2175
Synthesis, Structure, and Neuroprotective Properties of Novel Imidazolyl Nitrones
Alain Dhainaut,
André Tizot,
Eric Raimbaud,
Brian Lockhart,
Pierre Lestage, and
Solo Goldstein
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2176-2182
Population, Acid-Base, and Redox Properties of N-Acetylcysteine Conformers
Béla Noszál,
Dóra Visky, and
Márta Kraszni
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2183-2195
Design, Synthesis, and Structure-Activity Relationships of Phthalimide-Phenylpiperazines: A Novel Series of Potent and Selective  1a-Adrenergic Receptor Antagonists
Gee-Hong Kuo,
Catherine Prouty,
William V. Murray,
Virginia Pulito,
Linda Jolliffe,
Peter Cheung,
Sally Varga,
Mary Evangelisto, and
Jian Wang
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2196-2203
Methanocarba Analogues of Purine Nucleosides as Potent and Selective Adenosine Receptor Agonists
Kenneth A. Jacobson,
Xiao-duo Ji,
An-Hu Li,
Neli Melman,
Maqbool A. Siddiqui,
Kye-Jung Shin,
Victor E. Marquez, and
R. Gnana Ravi
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2204-2216
Predicting Blood-Brain Barrier Permeation from Three-Dimensional Molecular Structure
Patrizia Crivori,
Gabriele Cruciani,
Pierre-Alain Carrupt, and
Bernard Testa
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2217-2226
Novel Potent Ligands for the Central Nicotinic Acetylcholine Receptor: Synthesis, Receptor Binding, and 3D-QSAR Analysis
Simon Feldbæk Nielsen,
Elsebet Østergaard Nielsen,
Gunnar M. Olsen,
Tommy Liljefors, and
Dan Peters
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2227-2238
Isoquinoline and Quinazoline Urea Analogues as Antagonists for the Human Adenosine A3 Receptor
Jacqueline E. van Muijlwijk-Koezen,
Henk Timmerman,
Henk van der Goot,
Wiro M. P. B. Menge,
Jacobien Frijtag von Drabbe Künzel,
Miriam de Groote, and
Adriaan P. IJzerman
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2239-2247
Novel Inhibitors of Nucleoside Triphosphate Diphosphohydrolases: Chemical Synthesis and Biochemical and Pharmacological Characterizations
Fernand-Pierre Gendron,
Efrat Halbfinger,
Bilha Fischer,
Martine Duval,
Pédro D'Orléans-Juste, and
Adrien R. Beaudoin
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2248-2257
Anilides of (R)-Trifluoro-2-hydroxy-2-methylpropionic Acid as Inhibitors of Pyruvate Dehydrogenase Kinase
Gregory R. Bebernitz,,1
Thomas D. Aicher,,1,2
James L. Stanton,
Jiaping Gao,3
Suraj S. Shetty,3
Douglas C. Knorr,1
Robert J. Strohschein,1
Jennifer Tan,1
Leonard J. Brand,1
Charles Liu,1
Wei H. Wang,1
Christine C. Vinluan,4
Emma L. Kaplan,4
Carol J. Dragland,4
Dominick DelGrande,3
Amin Islam,3
Robert J. Lozito,3
Xilin Liu,3
Wieslawa M. Maniara, and
William R. Mann4
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2258-2265
Synthesis and Evaluation of Nitroheterocyclic Phosphoramidates as Hypoxia-Selective Alkylating Agents
Richard F. Borch,
Jiwen Liu,
James P. Schmidt,
Joseph T. Marakovits,
Carolyn Joswig,
Jerry J. Gipp, and
R. Timothy Mulcahy
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2266-2274
Synthesis, in Vitro Anti-Breast Cancer Activity, and Intracellular Decomposition of Amino Acid Methyl Ester and Alkyl Amide Phosphoramidate Monoesters of 3'-Azido-3'-deoxythymidine (AZT)
Vidhya V. Iyer,
George W. Griesgraber,
Matthew R. Radmer,
Edward J. McIntee, and
Carston R. Wagner
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BRIEF ARTICLES
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2275-2279
Quinolones: Novel Probes in Antifilarial Chemotheraphy
Sanjay K. Srivastava,
Prem M. S. Chauhan,
Amiya P. Bhaduri,
Nigar Fatima, and
Ranjit K. Chatterjee
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2280-2284
Modeling Cyclooxygenase Inhibition. Implication of Active Site Hydration on the Selectivity of Ketoprofen Analogues
Albert Palomer,
Juan J. Pérez,
Susana Navea,
Oriol Llorens,
Jaume Pascual,
Lluïsa García, and
David Mauleón
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2285-2289
Topoisomerase I-Mediated Antiproliferative Activity of Enantiomerically Pure Fluorinated Homocamptothecins
Olivier Lavergne,
Danièle Demarquay,
Christian Bailly,
Christophe Lanco,
Alain Rolland,
Marion Huchet,
Helène Coulomb,
Nicole Muller,
Nicole Baroggi,
José Camara,
Christine Le Breton,
Eric Manginot,
Jean-Bernard Cazaux, and
Dennis C. H. Bigg
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BOOK REVIEWS
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2290-2291
| Reviews in Computational Chemistry. Volume 13 Edited by Kenny B. Lipkowitz and Donald B. Boyd. Wiley-VCH, New York. 1999. xxxiii + 426 pp. 16 × 24 cm. ISBN 0471-33135-X. $135.00.
Peter A. Kollman
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2291-2291
| Second Supplements to the Second Edition of Rodd's Chemitry of Carbon Compounds. Volume IV: Heterocyclic Compounds. Part I. Six-membered Heterocyclic Compounds with Two Hetero-Atoms from Group V of the Periodic Table: the Pyridazine and Pyrimidine Groups. Part J. Six-membered Heterocyclic Compounds with Two Hetero-Atoms from Group V of the Periodic Table: the Pyrazine Group, Phenoxazine, Phenothiazine, Phenazine and Sulphur Dyes. Six-membered Heterocyclic Compounds with Three or More Hetero-Atoms Edited by M. Sainsbury. Elsevier, Amsterdam. 2000. xiv + 299 pp. 15 × 23 cm. ISBN-0-444-82980-6. $183.50.
Arnold Martin
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2291-2292
| Potassium Ion Channels: Molecular Structure, Function and Diseases Edited by Yoshihisa Kurachi, Lily Yeh Jan, and Michel Lazdunzki. Academic Press, San Diego, CA. 1999. xxiv + 492 pp. 15 × 22 cm. ISBN 0-12-153346-8. $99.95.
Murali Gopalakrishnan
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