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PERSPECTIVES
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281-297
| New Dermatological Agents for the Treatment of Psoriasis
Scott M. Thacher,
Jayasree Vasudevan,
Kwok-Yin Tsang,
Sunil Nagpal, and
Roshantha A. S. Chandraratna
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298-301
Design of Remarkably Simple, Yet Potent Urea-Based Inhibitors of Glutamate Carboxypeptidase II (NAALADase)
Alan P. Kozikowski,
Fajun Nan,
Paola Conti,
Jiazhong Zhang,
Epolia Ramadan,
Tomasz Bzdega,
Barbara Wroblewska,
Joseph H. Neale,
Sergey Pshenichkin, and
Jarda T. Wroblewski
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302-304
[3H]N-2-(4-(N-Benzamido)phenyl)propyl-2- propanesulfonamide: A Novel AMPA Receptor Potentiator and Radioligand
Hamideh Zarrinmayeh,
David Bleakman,
Mary R. Gates,
Hong Yu,
Dennis M. Zimmerman,
Paul L. Ornstein,
Tracey McKennon,
M. Brian Arnold,
William J. Wheeler, and
Phil Skolnick
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ARTICLES
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305-315
Quinoxalinylethylpyridylthioureas (QXPTs) as Potent Non-Nucleoside HIV-1 Reverse Transcriptase (RT) Inhibitors. Further SAR Studies and Identification of a Novel Orally Bioavailable Hydrazine-Based Antiviral Agent
Giuseppe Campiani,
Francesca Aiello,
Monica Fabbrini,
Elena Morelli,
Anna Ramunno,
Silvia Armaroli,
Vito Nacci,
Antonio Garofalo,
Giovanni Greco,
Ettore Novellino,
Giovanni Maga,
Silvio Spadari,
Alberto Bergamini,
Laura Ventura,
Barbara Bongiovanni,
Marcella Capozzi,
Francesca Bolacchi,
Stefano Marini,
Massimiliano Coletta,
Giovanna Guiso, and
Silvio Caccia
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316-327
3-Aryl[1,2,4]triazino[4,3-a]benzimidazol-4(10H)-ones: A New Class of Selective A1 Adenosine Receptor Antagonists
Federico Da Settimo,
Giampaolo Primofiore,
Sabrina Taliani,
Anna Maria Marini,
Concettina La Motta,
Ettore Novellino,
Giovanni Greco,
Antonio Lavecchia,
Letizia Trincavelli, and
Claudia Martini
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328-339
Design, Synthesis, and Modeling of Novel Cyclic Thrombin Receptor-Derived Peptide Analogues of the Ser42-Phe-Leu-Leu-Arg46 Motif Sequence with Fixed Conformations of Pharmacophoric Groups: Importance of a Phe/Arg/NH2 Cluster for Receptor Activation and Implications in the Design of Nonpeptide Thrombin Receptor Mimetics
Kostas Alexopoulos,
Dimitris Panagiotopoulos,
Thomas Mavromoustakos,
Panagiotis Fatseas,
Maria Christina Paredes-Carbajal,
Dieter Mascher,
Stefan Mihailescu, and
John Matsoukas
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340-349
Structure-Activity Relationships of Pyridoxal Phosphate Derivatives as Potent and Selective Antagonists of P2X1 Receptors
Yong-Chul Kim,
Sean G. Brown,
T. Kendall Harden,
José L. Boyer,
George Dubyak,
Brian F. King,
Geoffrey Burnstock, and
Kenneth A. Jacobson
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350-361
Synthesis and SAR of a New Series of COX-2-Selective Inhibitors: Pyrazolo[1,5-a]pyrimidines
Carmen Almansa,
Alberto F. de Arriba,
Fernando L. Cavalcanti,
Luis A. Gómez,
Agustí Miralles,
Manuel Merlos,
Julián García-Rafanell, and
Javier Forn
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362-371
Analogues of Prazosin That Bear a Benextramine-Related Polyamine Backbone Exhibit Different Antagonism toward  1-Adrenoreceptor Subtypes
Maria L. Bolognesi,
Gabriella Marucci,
Piero Angeli,
Michela Buccioni,
Anna Minarini,
Michela Rosini,
Vincenzo Tumiatti, and
Carlo Melchiorre
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372-389
Behavioral Approach to Nondyskinetic Dopamine Antagonists: Identification of Seroquel
Edward J. Warawa,
Bernard M. Migler,
Cyrus J. Ohnmacht,
Ann L. Needles,
George C. Gatos,
Frances M. McLaren,
Cynthia L. Nelson, and
Karen M. Kirkland
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390-403
Conformationally Restricted Analogues of 1N,14N-Bisethylhomospermine (BE-4-4-4): Synthesis and Growth Inhibitory Effects on Human Prostate Cancer Cells
Aldonia Valasinas,
Aparajita Sarkar,
Venodhar K. Reddy,
Laurence J. Marton,
Hirak S. Basu, and
Benjamin Frydman
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404-417
Cis-Unsaturated Analogues of 3,8,13,18,23-Pentaazapentacosane (BE-4-4-4-4): Synthesis and Growth Inhibitory Effects on Human Prostate Cancer Cell Lines
Venodhar K. Reddy,
Aparajita Sarkar,
Aldonia Valasinas,
Laurence J. Marton,
Hirak S. Basu, and
Benjamin Frydman
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418-428
New 1-Aryl-3-(4-arylpiperazin-1-yl)propane Derivatives, with Dual Action at 5-HT1A Serotonin Receptors and Serotonin Transporter, as a New Class of Antidepressants
Javier Martínez-Esparza,
Ana-M. Oficialdegui,
Silvia Pérez-Silanes,
Begoña Heras,
Lara Orús,
Juan-A. Palop,
Berta Lasheras,
Joan Roca,
Marisa Mourelle,
Ana Bosch,
Juan-C. Del Castillo,
Rosa Tordera,
Joaquín Del Río, and
Antonio Monge
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429-440
Tyrosine Kinase Inhibitors. 18. 6-Substituted 4-Anilinoquinazolines and 4-Anilinopyrido[3,4-d]pyrimidines as Soluble, Irreversible Inhibitors of the Epidermal Growth Factor Receptor
Jeff B. Smaill,
H. D. Hollis Showalter,
Hairong Zhou,
Alexander J. Bridges,
Dennis J. McNamara,
David W. Fry,
James M. Nelson,
Veronika Sherwood,
Patrick W. Vincent,
Bill J. Roberts,
William L. Elliott, and
William A. Denny
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441-452
Design, Synthesis, and Biological Evaluation of a Series of Lavendustin A Analogues That Inhibit EGFR and Syk Tyrosine Kinases, as Well as Tubulin Polymerization
Fanrong Mu,
Stephanie L. Coffing,
David J. Riese II,
Robert L. Geahlen,
Pascal Verdier-Pinard,
Ernest Hamel,
Jill Johnson, and
Mark Cushman
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453-467
GnRH Antagonists: A New Generation of Long Acting Analogues Incorporating p-Ureido-phenylalanines at Positions 5 and 6
Guangcheng Jiang,
Jacek Stalewski,
Robert Galyean,
John Dykert,
Claudio Schteingart,
Pierre Broqua,
Audrey Aebi,
Michel L. Aubert,
Graeme Semple,
Peter Robson,
Karen Akinsanya,
Robert Haigh,
Pierre Riviere,
Jerzy Trojnar,
Jean Louis Junien, and
Jean E. Rivier
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BRIEF ARTICLES
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468-471
Synthesis by Chemoselective Ligation and Biological Evaluation of Novel Cell-Permeable PKC- Pseudosubstrate Lipopeptides
Dominique Bonnet,
Kader Thiam,
Estelle Loing,
Oleg Melnyk, and
Hélène Gras-Masse
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472-474
Calculation of the Hydrophobicity of Platinum Drugs
James A. Platts,
David E. Hibbs,
Trevor W. Hambley, and
Matthew D. Hall
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BOOK REVIEWS
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475-475
| Oral Drug Absorption Prediction and Assessment Edited by Jennifer B. Dressman and Hans Lennermäs. Marcel Dekker, Inc., New York. 2000. x + 330 pp. 16 × 23.5 cm. ISBN 0-8247-0272-7. $165.00.
Mark Chasin
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475-476
| Seafood and Freshwater Toxins: Pharmacology, Physiology, and Detection Edited by L. M. Botana. Marcel Dekker, New York. 2000. xii + 798 pp. 18.5 × 26 cm. ISBN 0-8247-8956-3. $225.00.
J. Paul Hieble
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