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851-856
A Novel Series of Highly Potent Benzimidazole-Based Microsomal Triglyceride Transfer Protein Inhibitors
Jeffrey A. Robl,
Richard Sulsky,
Chong-Qing Sun,
Ligaya M. Simpkins,
Tammy Wang,
John K. Dickson, Jr.,
Ying Chen,
David R. Magnin,
Prakash Taunk,
William A. Slusarchyk,
Scott A. Biller,
Shih-Jung Lan,
Fergal Connolly,
Lori K. Kunselman,
Talal Sabrah,
Haris Jamil,
David Gordon,
Thomas W. Harrity, and
John R. Wetterau
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857-862
Investigation of the Selectivity of Oxymorphone- and Naltrexone-Derived Ligands via Site-Directed Mutagenesis of Opioid Receptors: Exploring the 'Address' Recognition Locus
Thomas G. Metzger,
M. Germana Paterlini,
David M. Ferguson, and
Philip S. Portoghese
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863-872
 2 Adrenoceptor Agonists as Potential Analgesic Agents. 3. Imidazolylmethylthiophenes
Robert E. Boyd,
C. Royce Rasmussen,
Jeffery B. Press,
Robert B. Raffa,
Ellen E. Codd,
Charlene D. Connelly,
Quan S. Li,
Rebecca P. Martinez,
Martin A. Lewis,
Harold R. Almond, and
Allen B. Reitz
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873-885
Inhibition of Heme Detoxification Processes Underlies the Antimalarial Activity of Terpene Isonitrile Compounds from Marine Sponges
Anthony D. Wright,
Huiqin Wang,
Marion Gurrath,
Gabriele M. König,
Gulcan Kocak,
Gregory Neumann,
Paul Loria,
Michael Foley, and
Leann Tilley
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886-897
Pharmacophore Analysis of the Nuclear Oxysterol Receptor LXR
Thomas A. Spencer,
Dansu Li,
Jonathon S. Russel,
Jon L. Collins,
Randy K. Bledsoe,
Thomas G. Consler,
Linda B. Moore,
Cristin M. Galardi,
David D. McKee,
John T. Moore,
Michael A. Watson,
Derek J. Parks,
Millard H. Lambert, and
Timothy M. Willson
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898-908
Molecular Modeling Studies of the Akt PH Domain and Its Interaction with Phosphoinositides
Suo-Bao Rong,
Youhong Hu,
Istvan Enyedy,
Garth Powis,
Emmanuelle J. Meuillet,
Xiongwu Wu,
Renxiao Wang,
Shaomeng Wang, and
Alan P. Kozikowski
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909-916
Bisphosphonates Inhibit the Growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: A Potential Route to Chemotherapy
Michael B. Martin,
Joshua S. Grimley,
Jared C. Lewis,
Huel T. Heath, III,
Brian N. Bailey,
Howard Kendrick,
Vanessa Yardley,
Aura Caldera,
Renee Lira,
Julio A. Urbina,
Silvia N. J. Moreno,
Roberto Docampo,
Simon L. Croft, and
Eric Oldfield
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917-922
A Potent, Nonpeptidyl 1H-Quinolone Antagonist for the Gonadotropin-Releasing Hormone Receptor
Robert J. DeVita,
Thomas F. Walsh,
Jonathan R. Young,
Jinlong Jiang,
Feroze Ujjainwalla,
Richard B. Toupence,
Mamta Parikh,
Song X. Huang,
Jason A. Fair,
Mark T. Goulet,
Matthew J. Wyvratt,
Jane-L. Lo,
Ning Ren,
Joel B. Yudkovitz,
Yi T. Yang,
Kang Cheng,
Jisong Cui,
George Mount,
Susan P. Rohrer,
James M. Schaeffer,
Linda Rhodes,
Jennifer E. Drisko,
Erin McGowan,
D. Euan MacIntyre,
Styliani Vincent,
Josephine R. Carlin,
Judith Cameron, and
Roy G. Smith
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923-930
High-Throughput Permeability pH Profile and High-Throughput Alkane/Water log P with Artificial Membranes
Frank Wohnsland and
Bernard Faller
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931-936
Synthesis of 2-Amino-5-sulfanyl-1,3,4-thiadiazole Derivatives and Evaluation of Their Antidepressant and Anxiolytic Activity
Francesca Clerici and
Donato Pocar
, Maddalena Guido,
Antonella Loche, and
Vincenzo Perlini
, Mario Brufani
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937-948
Structure-Activity Relationship Studies of 4-[2-(Diphenylmethoxy)ethyl]-1-benzylpiperidine Derivatives and Their N-Analogues: Evaluation of Behavioral Activity of O- and N-Analogues and Their Binding to Monoamine Transporters
Aloke K. Dutta,
Xiang-Shu Fei,
Patrick M. Beardsley,
Jennifer L. Newman, and
Maarten E. A. Reith
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949-960
New Synthesis of Benzo- -carbolines, Cryptolepines, and Their Salts: In Vitro Cytotoxic, Antiplasmodial, and Antitrypanosomal Activities of -Carbolines, Benzo--carbolines, and Cryptolepines
Erwan Arzel,
Patrick Rocca,
Philippe Grellier,
Mehdi Labaeïd,
François Frappier,
Françoise Guéritte,
Christiane Gaspard,
Francis Marsais,
Alain Godard, and
Guy Quéguiner
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961-971
Comparative Binding Energy (COMBINE) Analysis of Influenza Neuraminidase-Inhibitor Complexes
Ting Wang and
Rebecca C. Wade
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972-987
Factors Influencing Agonist Potency and Selectivity for the Opioid Receptor Are Revealed in Structure-Activity Relationship Studies of the 4-[(N-Substituted-4-piperidinyl)arylamino]-N,N-diethylbenzamides
James B. Thomas,
Xavier M. Herault,
Richard B. Rothman,
Robert N. Atkinson,
Jason P. Burgess,
S. Wayne Mascarella,
Christina M. Dersch,
Heng Xu,
Judith L. Flippen-Anderson,
Clifford F. George, and
F. Ivy Carroll
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988-1002
Discovery of Inhibitors of Cell Adhesion Molecule Expression in Human Endothelial Cells. 1. Selective Inhibition of ICAM-1 and E-Selectin Expression
Andrew O. Stewart,
Pramila A. Bhatia,
Catherine M. McCarty,
Meena V. Patel,
Michael A. Staeger,
David L. Arendsen,
Indrani W. Gunawardana,
Laura M. Melcher,
Gui-Dong Zhu,
Steven A. Boyd,
Dennis G. Fry,
Barbara L. Cool,
Lemma Kifle,
Kraig Lartey,
Kennan C. Marsh,
Anita J. Kempf-Grote,
Patrick Kilgannon,
Wendy Wisdom,
Joey Meyer,
W. Michael Gallatin, and
Gregory F. Okasinski
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1003-1010
Enantiospecific Synthesis and Pharmacological Evaluation of a Series of Super-Potent, Conformationally Restricted 5-HT2A/2C Receptor Agonists
James J. Chambers,
Deborah M. Kurrasch-Orbaugh,
Matthew A. Parker, and
David E. Nichols
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1011-1014
Solid-Phase Synthesis and Inhibitory Effects of Some Pyrido[1,2-c]pyrimidine Derivatives on Leukocyte Functions and Experimental Inflammation
Pedro Molina,
Enrique Aller,
Ángeles Lorenzo,
Pablo López-Cremades,
Inmaculada Rioja,
Amalia Ubeda,
Ma Carmen Terencio, and
Ma José Alcaraz
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1015-1015
| Solid-Phase Synthesis and Combinatorial Technologies By Pierfausto Seneci. Wiley-Interscience, New York. 2000. xii + 637 pp. 16 × 24 cm. ISBN 0471331953. $109.95.
Kennerly S. Patrick
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ADDITIONS AND CORRECTIONS
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1016-1016
| Carbonic Anhydrase and Matrix Metalloproteinase Inhibitors: Sulfonylated Amino Acid Hydroxamates with MMP Inhibitory Properties Act as Efficient Inhibitors of CA Isozymes I, II, and IV, and N-Hydroxysulfonamides Inhibit Both These Zinc Enzymes
Andrea Scozzafava and
Claudiu T. Supuran*:
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1016-1016
| Pyrido[2,3-d]pyrimidin-7-one Inhi-bitors of Cyclin-Dependent Kinases.
Mark Barvian,
Diane H. Boschelli,
Jennifer Cossrow,
Ellen Dobrusin,
Ali Fattaey,
Alex Fritsch,
David Fry,
Patricia Harvey,
Paul Keller,
Michelle Garrett,
Frances La,
Wilbur Leopold,
Dennis McNamara,
Maire Quin,
SusanneTrumpp-Kallmeyer,
Peter Toogood,
Zhipei Wu,and
Erli Zhang:
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