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1017-1020
Covalently Induced Activation of the  Opioid Receptor by a Fluorogenic Affinity Label, 7'-(Phthalaldehydecarboxamido)naltrindole (PNTI)
Bertrand Le Bourdonnec,
Rachid El Kouhen,
Gennady Poda,
Ping Y. Law,
Horace H. Loh,
David M. Ferguson, and
Philip S. Portoghese
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1021-1024
Discovery and Optimization of a Novel Series of Thrombin Receptor (PAR-1) Antagonists: Potent, Selective Peptide Mimetics Based on Indole and Indazole Templates
Han-Cheng Zhang,
Claudia K. Derian,
Patricia Andrade-Gordon,
William J. Hoekstra,
David F. McComsey,
Kimberly B. White,
Brenda L. Poulter,
Michael F. Addo,
Wai-Man Cheung,
Bruce P. Damiano,
Donna Oksenberg,
Elwood E. Reynolds,
Anjali Pandey,
Robert M. Scarborough, and
Bruce E. Maryanoff
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1025-1027
Substituted Pyrazolopyridines as Potent and Selective PDE5 Inhibitors: Potential Agents for Treatment of Erectile Dysfunction
Guixue Yu,
Helen J. Mason,
Ximao Wu,
Jian Wang,
Saeho Chong,
Gary Dorough,
Andrew Henwood,
Ronald Pongrac,
Laurie Seliger,
Bin He,
Diane Normandin,
Leonard Adam,
John Krupinski, and
John E. Macor
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1028-1034
Molecular Models of N-Benzyladriamycin-14-valerate (AD 198) in Complex with the Phorbol Ester-Binding C1b Domain of Protein Kinase C-
J. Brent Roaten,
Marcelo G. Kazanietz,
Trevor W. Sweatman,
Leonard Lothstein,
Mervyn Israel, and
Abby L. Parrill
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1035-1042
Detailed Analysis of Scoring Functions for Virtual Screening
Martin Stahl and
Matthias Rarey
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1043-1050
Estimation of Binding Affinities for Selective Thrombin Inhibitors via Monte Carlo Simulations
Albert C. Pierce and
William L. Jorgensen
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1051-1059
Synthesis and Pharmacology of 3-Isoxazolol Amino Acids as Selective Antagonists at Group I Metabotropic Glutamic Acid Receptors
Ulf Madsen,
Hans Bräuner-Osborne,
Karla Frydenvang,
Lise Hvene,
Tommy N. Johansen,
Birgitte Nielsen,
Connie Sánchez,
Tine B. Stensb l,
Francois Bischoff, and
Povl Krogsgaard-Larsen
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1060-1071
Development of New Carboxylic Acid-Based MMP Inhibitors Derived from Functionalized Propargylglycines
Michael G. Natchus,
Roger G. Bookland,
Matthew J. Laufersweiler,
Staszek Pikul,
Neil G. Almstead,
Biswanath De,
Michael J. Janusz,
Lily C. Hsieh,
Fei Gu,
Matthew E. Pokross,
Vikram S. Patel,
Susan M. Garver,
Sean X. Peng,
Todd M. Branch,
Selane L. King,
Timothy R. Baker,
David J. Foltz, and
Glen E. Mieling
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1072-1084
Flexible Estrogen Receptor Modulators: Design, Synthesis, and Antagonistic Effects in Human MCF-7 Breast Cancer Cells
Mary J. Meegan,
Rosario B. Hughes,
David G. Lloyd,
D. Clive Williams, and
Daniela M. Zisterer
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1085-1098
Cardioselective KATP Channel Blockers Derived from a New Series of m-Anisamidoethylbenzenesulfonylthioureas
Heinrich C. Englert,
Uwe Gerlach,
Heinz Goegelein,
Jens Hartung,
Holger Heitsch,
Dieter Mania, and
Sabine Scheidler
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1099-1115
Progress toward the Development of a Safe and Effective Agent for Treating Reentrant Cardiac Arrhythmias: Synthesis and Evaluation of Ibutilide Analogues with Enhanced Metabolic Stability and Diminished Proarrhythmic Potential
Jackson B. Hester,
John K. Gibson,
Lewis V. Buchanan,
Madeline G. Cimini,
Michael A. Clark,
D. Edward Emmert,
Michael A. Glavanovich,
Rick J. Imbordino,
Richelle J. LeMay,
Moses W. McMillan,
Salvatore C. Perricone,
Donald M. Squires, and
Rodney R. Walters
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1116-1121
Synthesis and Biodistribution of a New Oxo-technetium-99m Bis(aminothiol) Complex as a Potential Melanoma Tracer
Philippe Auzeloux,
Janine Papon,
Roberto Pasqualini, and
Jean-Claude Madelmont
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1122-1122
| Circular Dichroism. Principles and Applications, Second Edition Edited by Nina Berova, Koji Nakanishi, and Robert W. Woody. Wiley-VCH Publishers, New York. 2000. xix + 877 pp. 18.5 × 26 cm. ISBN 0 47133003 5. $195.00.
R. Lee Webb
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1122-1123
| Natural Extracts Using Supercritical Carbon Dioxide By Mamata Mukhopadhyay. CRC Press, Boca Raton, FL. 2000. 319 pp. 16 × 24 cm. ISBN 0-8493-0819-4. $99.95.
Govind J. Kapadia
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1123-1123
| Practical Process Research & Development By Neal G. Anderson. Academic Press, San Diego, CA. 2000. xxiii + 354 pp. 15.5 × 24 cm. ISBN 0-12-059475-7. $89.95.
Christopher R. Schmid
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ADDITIONS AND CORRECTIONS
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1124-1124
| Simulations of the Estrogen Receptor Ligand-Binding Domain: Affinity of Natural Ligands and Xenoestrogens.
B. Chris Oostenbrink,
Jed W. Pitera,
Marola M. H.
van Lipzig,
John H. N. Meerman, and
Wilfred F.
van Gunsteren:
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