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1125-1133
Nonpeptide Cholecystokinin-2 Receptor Agonists
S. Barret Kalindjian,
David J. Dunstone,
Caroline M. R. Low,
Michael J. Pether,
Sonia P. Roberts,
Matthew J. Tozer,
Gillian F. Watt, and
Nigel P. Shankley
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1134-1150
Mapping and Fitting the Peripheral Benzodiazepine Receptor Binding Site by Carboxamide Derivatives. Comparison of Different Approaches to Quantitative Ligand-Receptor Interaction Modeling
Maurizio Anzini,
Andrea Cappelli,
Salvatore Vomero,
Michele Seeber,$
Maria Cristina Menziani,$
Thierry Langer,
Bertram Hagen,
Cristina Manzoni, and
Jean-Jacques Bourguignon
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1151-1157
Comparative Molecular Field Analysis of Dopamine D4 Receptor Antagonists Including 3-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]pyrazolo[1,5-a]pyridine (FAUC 113), 3-[4-(4-Chlorophenyl)piperazin-1-ylmethyl]-1H-pyrrolo[2,3-b]pyridine (L-745,870), and Clozapine
Harald Lanig,
Wolfgang Utz, and
Peter Gmeiner
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1158-1176
Discovery of an Orally Active Non-Peptide Fibrinogen Receptor Antagonist Based on the Hydantoin Scaffold
Hans Ulrich Stilz,
Wolfgang Guba,
Bernd Jablonka,
Melitta Just,
Otmar Klingler,
Wolfgang König,
Volkmar Wehner, and
Gerhard Zoller
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1177-1184
Latent Semantic Structure Indexing (LaSSI) for Defining Chemical Similarity
Richard D. Hull,
Suresh B. Singh,
Robert B. Nachbar,
Robert P. Sheridan,
Simon K. Kearsley, and
Eugene M. Fluder
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1185-1191
Chemical Similarity Searches Using Latent Semantic Structural Indexing (LaSSI) and Comparison to TOPOSIM
Richard D. Hull,
Eugene M. Fluder,
Suresh B. Singh,
Robert B. Nachbar,
Simon K. Kearsley, and
Robert P. Sheridan
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1192-1201
Design, Synthesis, and Structural Analysis of Influenza Neuraminidase Inhibitors Containing Pyrrolidine Cores
Gary T. Wang,
Yuanwei Chen,
Sheldon Wang,
Robert Gentles,
Thomas Sowin,
Warren Kati,
Steve Muchmore,
Vincent Giranda,
Kent Stewart,
Hing Sham,
Dale Kempf, and
W. Graeme Laver
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1202-1210
Novel p-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 2. Mechanism of Inhibition and Structure-Based Improvement of Pharmaceutical Properties
Gang Liu,
Jeffrey R. Huth,
Edward T. Olejniczak,
Renaldo Mendoza,
Peter DeVries,
Sandra Leitza,
Edward B. Reilly,
Gregory F. Okasinski,
Stephen W. Fesik, and
Thomas W. von Geldern
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1211-1216
Acyl Substitution at the Ortho Position of Anilides Enhances Oral Bioavailability of Thiophene Sulfonamides: TBC3214, an ETA Selective Endothelin Antagonist
Chengde Wu,
E. Radford Decker,
Natalie Blok,
Jian Li,
Andree R. Bourgoyne,
Huong Bui,
Karin M. Keller,
Vippra Knowles,
Wen Li,
Fiona D. Stavros,
George W. Holland,
Tommy A. Brock, and
Richard A. F. Dixon
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1217-1230
Synthesis and Biological Activity of Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid: Discovery of a Novel Aminoguanidinoacetic Acid Antidiabetic Agent
Scott D. Larsen,
Mark A. Connell,
Michele M. Cudahy,
Bruce R. Evans,
Paul D. May,
Martin D. Meglasson,
Theresa J. O'Sullivan,
Heinrich J. Schostarez,
John C. Sih,
F. Craig Stevens,
Steven P. Tanis,
Christopher M. Tegley,
John A. Tucker,
Valerie A. Vaillancourt,
Thomas J. Vidmar,
William Watt, and
Jen H. Yu
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1231-1248
Synthesis and Biological Activity of Aminoguanidine and Diaminoguanidine Analogues of the Antidiabetic/Antiobesity Agent 3-Guanidinopropionic Acid
Valerie A. Vaillancourt,
Scott D. Larsen,
Steven P. Tanis,
Jeffery E. Burr,
Mark A. Connell,
Michele M. Cudahy,
Bruce R. Evans,
Peter V. Fisher,
Paul D. May,
Martin D. Meglasson,
Deborah D. Robinson,
F. Craig Stevens,
John A. Tucker,
Thomas J. Vidmar, and
Jen H. Yu
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1249-1256
Angular Methoxy-Substituted Furo- and Pyranoquinolinones as Blockers of the Voltage-Gated Potassium Channel Kv1.3
Inga Butenschön,
Kerstin Möller, and
Wolfram Hänsel
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1257-1267
New Selective Cytotoxic Diterpenylquinones and Diterpenylhydroquinones
José Ma Miguel del Corral,
Marina Gordaliza,
Ma Angeles Castro,
Ma Mar Mahiques,
Pablo Chamorro,
Aurora Molinari,
Ma Dolores García-Grávalos,
Howard B. Broughton, and
Arturo San Feliciano
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1268-1285
Development of Orally Active Nonpeptidic Inhibitors of Human Neutrophil Elastase
Kazuyuki Ohmoto,
Tetsuya Yamamoto,
Motohiro Okuma,
Toshihide Horiuchi,
Hirotoshi Imanishi,
Yoshihiko Odagaki,
Kazuhito Kawabata,
Tomohiko Sekioka,
Yasushi Hirota,
Shozo Matsuoka,
Hisao Nakai, and
Masaaki Toda
, John C. Cheronis,
Lyle W. Spruce,
Albert Gyorkos, and
Maciej Wieczorek
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1286-1296
Synthesis, Structure-Activity Relationships, and Pharmacokinetic Profiles of Nonpeptidic  -Keto Heterocycles as Novel Inhibitors of Human Chymase
Fumihiko Akahoshi,
Atsuyuki Ashimori,
Hiroshi Sakashita,
Takuya Yoshimura,
Teruaki Imada,
Masahide Nakajima,
Naoko Mitsutomi,
Shigeki Kuwahara,
Tatsuyuki Ohtsuka,
Chikara Fukaya,
Mizuo Miyazaki, and
Norifumi Nakamura
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1297-1304
Synthesis, Structure-Activity Relationships, and Pharmacokinetic Profiles of Nonpeptidic Difluoromethylene Ketones as Novel Inhibitors of Human Chymase
Fumihiko Akahoshi,
Atsuyuki Ashimori,
Hiroshi Sakashita,
Takuya Yoshimura,
Masahiro Eda,
Teruaki Imada,
Masahide Nakajima,
Naoko Mitsutomi,
Shigeki Kuwahara,
Tatsuyuki Ohtsuka,
Chikara Fukaya,
Mizuo Miyazaki, and
Norifumi Nakamura
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1305-1311
Highly Potent and Subtype Selective Ligands Derived by N-Methyl Scan of a Somatostatin Antagonist
W. G. Rajeswaran,
Simon J. Hocart,
William A. Murphy,
John E. Taylor, and
David H. Coy
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1312-1312
| Reactive Oxygen Metabolites. Chemistry and Medical Consequences By Manfred K. Eberhardt. CRC Press, Boca Raton, FL. 2001. 591 pp. 16 × 24 cm. ISBN 0-8493-0891-7. $119.95.
Kenneth G. Holden
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