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1479-1482
Highly Selective and Potent Neuropeptide Y (NPY) Y1 Receptor Antagonists Based on [Pro30, Tyr32, Leu34]NPY(28-36)-NH2 (BW1911U90)
Ambikaipakan Balasubramaniam,
Vikas C. Dhawan,
Deborra E. Mullins,
William T. Chance,
Sulaiman Sheriff,
Mario Guzzi,
M. Prabhakaran, and
Eric M. Parker
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1483-1490
Flexible Alignment of Small Molecules
Paul Labute and
Chris Williams
, Miklos Feher,
Elizabeth Sourial, and
Jonathan M. Schmidt
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1491-1508
Design, Synthesis, and Proposed Active Site Binding Analysis of Monocyclic 2-Azetidinone Inhibitors of Prostate Specific Antigen
Robert M. Adlington,
Jack E. Baldwin,
Gerald W. Becker,
Beining Chen,
Leifeng Cheng,
Stephen L. Cooper,
Robert B. Hermann,
Trevor J. Howe,
William McCoull,
Ann M. McNulty,
Blake L. Neubauer, and
Gareth J. Pritchard
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1509-1515
Synthesis of 2 -Acyl-3-(substituted naphthyl)-8-azabicyclo[3.2.1]octanes and Their Binding Affinities at Dopamine and Serotonin Transport Sites
Huw M. L. Davies,
Vernon Gilliatt,
Lisa A. Kuhn,
Elie Saikali,
Pingda Ren,
Philip S. Hammond,
Tammy Sexton, and
Steven R. Childers
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1516-1529
Design, Synthesis, SAR, and Biological Evaluation of Highly Potent Benzimidazole-Spaced Phosphono- -Amino Acid Competitive NMDA Antagonists of the AP-6 Type
Reinhardt B. Baudy,
Horace Fletcher III,
John P. Yardley,
Margaret M. Zaleska,
Donna R. Bramlett,
Rene P. Tasse,
Dianne M. Kowal,
Alan H. Katz,
John A. Moyer, and
Magid Abou-Gharbia
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1530-1539
Computational Analysis of PKA-Balanol Interactions
Chung F. Wong,
Philippe H. Hünenberger,
Pearl Akamine,
Narendra Narayana,
Tom Diller,
J. Andrew McCammon,
Susan Taylor, and
Nguyen-Huu Xuong
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1540-1559
Synthesis, Photophysical Properties, Tumor Uptake, and Preliminary in Vivo Photosensitizing Efficacy of a Homologous Series of 3-(1'-Alkyloxy)ethyl-3-devinylpurpurin-18-N-alkylimides with Variable Lipophilicity
Gang Zheng,
William R. Potter,
Susan H. Camacho,
Joseph R. Missert,
Guosheng Wang,
David A. Bellnier,
Barbara W. Henderson,
Michael A. J. Rodgers,
Thomas J. Dougherty, and
Ravindra K. Pandey
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1560-1563
Antimycobacterial Activity of Substituted Isosteres of Pyridine- and Pyrazinecarboxylic Acids. 2.
Mikail H. Gezginci,
Arnold R. Martin, and
Scott G. Franzblau
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1564-1575
Mining the Chemical Quarry with Joint Chemical Probes: An Application of Latent Semantic Structure Indexing (LaSSI) and TOPOSIM (Dice) to Chemical Database Mining
Suresh B. Singh,
Robert P. Sheridan,
Eugene M. Fluder, and
Richard D. Hull
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1576-1587
Synthesis and NMR-Driven Conformational Analysis of Taxol Analogues Conformationally Constrained on the C13 Side Chain
Luciano Barboni and
Catia Lambertucci
, Giovanni Appendino
, David G. Vander Velde and
Richard H. Himes
, Ezio Bombardelli
, Minmin Wang and
James P. Snyder
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1588-1593
Synthesis and Biological Evaluation of Pyrrolinic Isosteres of Rilmenidine. Discovery of cis-/trans-Dicyclopropylmethyl-(4,5-dimethyl-4,5-dihydro-3H- pyrrol-2-yl)-amine (LNP 509), an I1 Imidazoline Receptor Selective Ligand with Hypotensive Activity
Stephan Schann,
Véronique Bruban,
Kenia Pompermayer,
Josiane Feldman,
Bruno Pfeiffer,
Pierre Renard,
Elizabeth Scalbert,
Pascal Bousquet, and
Jean-Daniel Ehrhardt
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1594-1602
Synthesis and Biological Evaluation of Novel A-Ring Modified Hexacyclic Camptothecin Analogues
Dae-Kee Kim,
Do Hyun Ryu,
Ju Young Lee,
Namkyu Lee,
Young-Woo Kim,
Jae-Sun Kim,
Kieyoung Chang,
Guang-Jin Im,
Tae-Kon Kim, and
Won-Son Choi
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1603-1614
3-(4-Fluoropiperidin-3-yl)-2-phenylindoles as High Affinity, Selective, and Orally Bioavailable h5-HT2A Receptor Antagonists
Michael Rowley,
David J. Hallett,
Simon Goodacre,
Christopher Moyes,
James Crawforth,
Timothy J. Sparey,
Smita Patel,
Rose Marwood,
Shil Patel,
Steven Thomas,
Laure Hitzel,
Desmond O'Connor,
Nicola Szeto,
Jose L. Castro,
Peter H. Hutson, and
Angus M. MacLeod
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1615-1622
Pharmacological and Behavioral Analysis of the Effects of Some Bivalent Ligand-Based Monoamine Reuptake Inhibitors
Amir P. Tamiz,
Bidhan C. Bandyopadhyay,
Jianrong Zhang,
Judith L. Flippen-Anderson,
Mei Zhang,
Chen Z. Wang,
Kenneth M. Johnson,
Srihari Tella, and
Alan P. Kozikowski
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1623-1626
Combinatorial Lead Optimization of a Neuropeptide FF Antagonist
Laszlo Prokai,
Katalin Prokai-Tatrai,
Alevtina Zharikova,
Xiaoxu Li, and
James R. Rocca
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