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1627-1653
| Recent Developments in the Biology and Medicinal Chemistry of Potassium Channel Modulators: Update from a Decade of Progress
Michael J. Coghlan,
William A. Carroll, and
Murali Gopalakrishnan
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1654-1657
Design, Synthesis, and Preclinical Characterization of Novel, Highly Selective Indole Estrogens
Chris P. Miller,
Michael D. Collini,
Bach D. Tran,
Heather A. Harris,
Yogendra P. Kharode,
James T. Marzolf,
Robert A. Moran,
Ruth A. Henderson,
Reinhold H. W. Bender,
Rayomond J. Unwalla,
Lee M. Greenberger,
John P. Yardley,
Magid A. Abou-Gharbia,
C. Richard Lyttle, and
Barry S. Komm
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1658-1665
Antiplasmodial Activity and Cytotoxicity of Bis-, Tris-, and Tetraquinolines with Linear or Cyclic Amino Linkers
Sophie Girault,
Philippe Grellier,
Amaya Berecibar,
Louis Maes,
Pascal Lemière,
Elisabeth Mouray,
Elisabeth Davioud-Charvet, and
Christian Sergheraert
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1666-1674
Development of a Pharmacophore Model for Histamine H3 Receptor Antagonists, Using the Newly Developed Molecular Modeling Program SLATE
Iwan J. P. De Esch,
James E. J. Mills,
Tim D. J. Perkins,
Giuseppe Romeo,
Marcel Hoffmann,
Kerstin Wieland,
Rob Leurs,
Wiro M. P. B. Menge,
Paul H. J. Nederkoorn,
Philip M. Dean, and
Henk Timmerman
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1675-1689
Stepwise Modulation of Neurokinin-3 and Neurokinin-2 Receptor Affinity and Selectivity in Quinoline Tachykinin Receptor Antagonists
Frank E. Blaney,
Luca F. Raveglia,
Marco Artico,
Stefano Cavagnera,
Catherine Dartois,
Carlo Farina,
Mario Grugni,
Stefania Gagliardi,
Mark A. Luttmann,
Marisa Martinelli,
Guy M. M. G. Nadler,
Carlo Parini,
Paola Petrillo,
Henry M. Sarau,
Mark A. Scheideler,
Douglas W. P. Hay, and
Giuseppe A. M. Giardina
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1690-1701
Structural Basis of Binding of High-Affinity Ligands to Protein Kinase C: Prediction of the Binding Modes through a New Molecular Dynamics Method and Evaluation by Site-Directed Mutagenesis
Youngshang Pak,
Istvan J. Enyedy,
Judith Varady,
Justin W. Kung,
Patricia S. Lorenzo,
Peter M. Blumberg, and
Shaomeng Wang
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1702-1709
Ether Phospholipid-AZT Conjugates Possessing Anti-HIV and Antitumor Cell Activity. Synthesis, Conformational Analysis, and Study of Their Thermal Effects on Membrane Bilayers
Thomas Mavromoustakos,
Theodora Calogeropoulou,
Maria Koufaki,
Antonios Kolocouris,
Ioanna Daliani,
Costas Demetzos,
Zhaoxing Meng,
Alexandros Makriyannis,
Jan Balzarini, and
Erik De Clercq
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1710-1717
Quinazolin-4-one  -Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid (AMPA) Receptor Antagonists: Structure-Activity Relationship of the C-2 Side Chain Tether
Bertrand L. Chenard,
Willard M. Welch,
James F. Blake,
Todd W. Butler,
Anthony Reinhold,
Frank E. Ewing,
Frank S. Menniti, and
Martin J. Pagnozzi
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1718-1728
Discovery of Novel Aldose Reductase Inhibitors Using a Protein Structure-Based Approach: 3D-Database Search Followed by Design and Synthesis
Yoriko Iwata,
Mitsuhiro Arisawa,
Ryuji Hamada,
Yasuyuki Kita,
Miho Y. Mizutani,
Nobuo Tomioka,
Akiko Itai, and
Shuichi Miyamoto
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1729-1740
Homology Modeling Using Multiple Molecular Dynamics Simulations and Docking Studies of the Human Androgen Receptor Ligand Binding Domain Bound to Testosterone and Nonsteroidal Ligands
Craig A. Marhefka,
Bob M. Moore II,
Thomas C. Bishop,
Leonid Kirkovsky,
Arnab Mukherjee,
James T. Dalton, and
Duane D. Miller
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1741-1748
Diguanidino and "Reversed" Diamidino 2,5-Diarylfurans as Antimicrobial Agents
Chad E. Stephens,
Farial Tanious,
Susan Kim,
W. David Wilson,
Wiley A. Schell,
John R. Perfect,
Scott G. Franzblau, and
David W. Boykin
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1749-1757
Synthesis and Biological Evaluation of Purine-Containing Butenolides
Gholam H. Hakimelahi,
Nai-Wen Mei,
Ali A. Moosavi-Movahedi,
Hady Davari,
Shahram Hakimelahi,
Ke-Yung King,
Jih Ru Hwu, and
Yuh-Sheng Wen
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1758-1776
Design, Synthesis, and Biological Evaluation of Analogues of the Antitumor Agent, 2-{4-[(7-Chloro-2-quinoxalinyl)oxy]phenoxy}propionic Acid (XK469)
Stuart T. Hazeldine,
Lisa Polin,
Juiwanna Kushner,
Jennifer Paluch,
Kathryn White,
Matthew Edelstein,
Eduardo Palomino,
Thomas H. Corbett, and
Jerome P. Horwitz
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1777-1793
Potent Reversible Inhibitors of the Protein Tyrosine Phosphatase CD45
Rebecca A. Urbanek,
Suzanne J. Suchard,
Gary B. Steelman,
Katharine S. Knappenberger,
Linda A. Sygowski,
Chris A. Veale, and
Marc J. Chapdelaine
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1794-1801
Enantioselective Syntheses of Dopaminergic (R)- and (S)-Benzyltetrahydroisoquinolines
Nuria Cabedo,
Inmaculada Andreu,
M. Carmen Ramírez de Arellano,
Abdeslam Chagraoui,
Angel Serrano,
Almudena Bermejo,
Philippe Protais, and
Diego Cortes
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1802-1814
Estradiol-16-carboxylic Acid Esters as Locally Active Estrogens
David C. Labaree,
Toni Y. Reynolds, and
Richard B. Hochberg
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1815-1826
Synthesis and Structure-Activity Relationships of Naphthamides as Dopamine D3 Receptor Ligands
Yunsheng Huang,
Robert R. Luedtke,
Rebekah A. Freeman,
Li Wu, and
Robert H. Mach
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1827-1832
QSAR and Molecular Modeling Studies of Baclofen Analogues as GABAB Agonists. Insights into the Role of the Aromatic Moiety in GABAB Binding and Activation
Gabriele Costantino,
Antonio Macchiarulo,
Antonio Entrena Guadix, and
Roberto Pellicciari
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1833-1836
Phenanthroindolizidine Alkaloids as Cytotoxic Substances in a Danaid Butterfly, Ideopsis similis, against Human Cancer Cells
Hajime Komatsu,
Masahiko Watanabe,
Masayoshi Ohyama,
Takeji Enya,
Kotaro Koyama,
Takashi Kanazawa,
Nobuo Kawahara,
Takashi Sugimura, and
Keiji Wakabayashi
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1837-1840
The Role of Sugar Residues in Molecular Recognition by Vancomycin
Jeffrey Kaplan,
Brian D. Korty,
Paul H. Axelsen, and
Patrick J. Loll
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