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1841-1846
Simple Selection Criteria for Drug-like Chemical Matter
Ingo Muegge,
Sarah L. Heald, and
David Brittelli
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1847-1852
2-(2-Oxo-1,4-dihydro-2H-quinazolin-3-yl)- and 2-(2,2-Dioxo-1,4-dihydro-2H-2 6-benzo[1,2,6]thiadiazin-3-yl)-N-hydroxy-acetamides as Potent and Selective Peptide Deformylase Inhibitors
Christian Apfel,
David W. Banner,
Daniel Bur,
Michel Dietz,
Christian Hubschwerlen,
Hans Locher,
Frédéric Marlin,
Raffaello Masciadri,
Wolfgang Pirson, and
Henri Stalder
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1853-1865
Identification of a Putative Binding Site for [2',5'-Bis-O-(tert-butyldimethylsilyl)- -D-ribofuranosyl]-3'-spiro-5' '-(4' '-amino-1' ',2' '-oxathiole-2' ',2' '-dioxide)thymine (TSAO) Derivatives at the p51-p66 Interface of HIV-1 Reverse Transcriptase
Fátima Rodríguez-Barrios,
Carlos Pérez,
Esther Lobatón,
Sonsoles Velázquez,
Cristina Chamorro,
Ana San-Félix,
María-Jesús Pérez-Pérez,
María-José Camarasa,
Heidi Pelemans,
Jan Balzarini, and
Federico Gago
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1866-1882
2-Amino-6-arylsulfonylbenzonitriles as Non-nucleoside Reverse Transcriptase Inhibitors of HIV-1
Joseph H. Chan,
Jean S. Hong,
Robert N. Hunter III,
G. Faye Orr,
Jill R. Cowan,
Douglas B. Sherman,
Steven M. Sparks,
Barbara E. Reitter,
C. Webster Andrews III,
Richard J. Hazen,
Marty St Clair,
Lawrence R. Boone,
Rob G. Ferris,
Katrina L. Creech,
Grace B. Roberts,
Steven A. Short,
Kurt Weaver,
Ronda J. Ott,
Jingshan Ren,
Andrew Hopkins,
David I. Stuart, and
David K. Stammers
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1883-1891
3D-QSAR Model of Flavonoids Binding at Benzodiazepine Site in GABAA Receptors
Xiaoqin Huang,
Tong Liu,
Jiande Gu,
Xiaomin Luo,
Ruyun Ji,
Yang Cao,
Hong Xue,
J. Tze-Fei Wong,
Bing L. Wong,
Gang Pei,
Hualiang Jiang, and
Kaixian Chen
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1892-1904
An Optimized Protein Kinase C Activating Diacylglycerol Combining High Binding Affinity (Ki) with Reduced Lipophilicity (log P)
Kassoum Nacro,
Dina M. Sigano,
Shunqi Yan,
Marc C. Nicklaus,
Larry L. Pearce,
Nancy E. Lewin,
Susan H. Garfield,
Peter M. Blumberg, and
Victor E. Marquez
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1905-1914
Radioiodinated Styrylbenzenes and Thioflavins as Probes for Amyloid Aggregates
Z.-P. Zhuang,
M.-P. Kung,
C. Hou,
D. M. Skovronsky,
T. L. Gur,
K. Plössl,
J. Q. Trojanowski,
V. M.-Y. Lee, and
H. F. Kung
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1915-1926
Soluble 2-Substituted Aminopyrido[2,3-d]pyrimidin-7-yl Ureas. Structure-Activity Relationships against Selected Tyrosine Kinases and Exploration of in Vitro and in Vivo Anticancer Activity
Mel C. Schroeder,
James M. Hamby,
Cleo J. C. Connolly,
Patrick J. Grohar,
R. Thomas Winters,
Mark R. Barvian,
Charles W. Moore,
Stacey L. Boushelle,
Sheila M. Crean,
Alan J. Kraker,
Denise L. Driscoll,
Patrick W. Vincent,
William L. Elliott,
Gina H. Lu,
Brian L. Batley,
Tawny K. Dahring,
Terry C. Major,
Robert L. Panek,
Annette M. Doherty, and
H. D. Hollis Showalter
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1927-1937
Experimental and Computational Screening Models for the Prediction of Intestinal Drug Absorption
Patric Stenberg,
Ulf Norinder,
Kristina Luthman, and
Per Artursson
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1938-1950
Solid-Phase Synthesis of a Nonpeptide RGD Mimetic Library: New Selective  v3 Integrin Antagonists
Gábor A. G. Sulyok,
Christoph Gibson,
Simon L. Goodman,
Günter Hölzemann,
Matthias Wiesner, and
Horst Kessler
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1951-1962
Structure-Activity Relationships of 1,4-Dihydro-(1H,4H)-quinoxaline-2,3-diones as N-Methyl-D-aspartate (Glycine Site) Receptor Antagonists. 1. Heterocyclic Substituted 5-Alkyl Derivatives
M. Jonathan Fray,
David J. Bull,
Christopher L. Carr,
Elisabeth C. L. Gautier,
Charles E. Mowbray, and
Alan Stobie
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1963-1970
Investigations of New Lead Structures for the Design of Selective Estrogen Receptor Modulators
Ronald Gust,
Roland Keilitz, and
Kathrin Schmidt
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1971-1985
Structure-Activity Studies for a Novel Series of Bicyclic Substituted Hexahydrobenz[e]isoindole 1A Adrenoceptor Antagonists as Potential Agents for the Symptomatic Treatment of Benign Prostatic Hyperplasia
Michael D. Meyer,
Robert J. Altenbach,
Hao Bai,
Fatima Z. Basha,
William A. Carroll,
James F. Kerwin, Jr.,
Suzanne A. Lebold,
Edmund Lee,
John K. Pratt,
Kevin B. Sippy,
Karin Tietje,
Michael D. Wendt,
Michael E. Brune,
Steven A. Buckner,
Arthur A. Hancock, and
Irene Drizin
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1986-1992
Aromatic Quinolinecarboxamides as Selective, Orally Active Antibody Production Inhibitors for Prevention of Acute Xenograft Rejection
Christos Papageorgiou,
Anette von Matt,
Joanne Joergensen,
Elsebeth Andersen,
Katrin Wagner,
Christian Beerli,
Thai Than,
Xaver Borer,
Andrea Florineth,
Gretty Rihs,
Max H. Schreier,
Gisbert Weckbecker, and
Christoph Heusser
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1993-2003
Synthesis, Antifolate, and Antitumor Activities of Classical and Nonclassical 2-Amino-4-oxo-5-substituted-pyrrolo[2,3-d]pyrimidines
Aleem Gangjee,
Anup Vidwans,
Elfatih Elzein,
John J. McGuire,
Sherry F. Queener, and
Roy L. Kisliuk
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2004-2014
Synthesis and Cytotoxic Activity of 7-Oxo-7H-dibenz[f,ij]isoquinoline and 7-Oxo-7H-benzo[e]perimidine Derivatives
Xianyong Bu,
Leslie W. Deady,
Graeme J. Finlay,
Bruce C. Baguley, and
William A. Denny
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2015-2026
Potent and Selective Nonpeptide Inhibitors of Caspases 3 and 7
Dennis Lee,
Scott A. Long,
Jeffrey H. Murray,
Jerry L. Adams,
Mark E. Nuttall,
Daniel P. Nadeau,
Kristine Kikly,
James D. Winkler,
Chiu-Mei Sung,
M. Dominic Ryan,
Mark A. Levy,
Paul M. Keller, and
Walter E. DeWolf, Jr.
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2027-2034
Metabolism of Sirolimus and Its Derivative Everolimus by Cytochrome P450 3A4: Insights from Docking, Molecular Dynamics, and Quantum Chemical Calculations
Bernd Kuhn,
Wolfgang Jacobsen,
Uwe Christians,
Leslie Z. Benet, and
Peter A. Kollman
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2035-2038
Preparation and Properties of S-Nitroso-L-Cysteine Ethyl Ester, an Intracellular Nitrosating Agent
Robert Clancy,
Arthur I. Cederbaum, and
Detcho A. Stoyanovsky
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