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4497-4500
Synthesis and Biological Evaluation of Myoseverin Derivatives: Microtubule Assembly Inhibitors
Young-Tae Chang,
Sarah M. Wignall,
Gustavo R. Rosania,
Nathanael S. Gray,
Sarah R. Hanson,
Andrew I. Su,
John Merlie, Jr.,
Ho-Sang Moon,
Sameep B. Sangankar,
Omar Perez,
Rebecca Heald, and
Peter G. Schultz
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4501-4504
Characterization of the 1H-Cyclopentapyrimidine-2,4(1H,3H)-dione Derivative (S)-CPW399 as a Novel, Potent, and Subtype-Selective AMPA Receptor Full Agonist with Partial Desensitization Properties
Giuseppe Campiani,
Elena Morelli,
Vito Nacci,
Caterina Fattorusso,
Anna Ramunno,
Ettore Novellino,
Jeremy Greenwood,
Tommy Liljefors,
Roger Griffiths,
Colin Sinclair,
Helen Reavy,
Anders S. Kristensen,
Darryl S. Pickering,
Arne Schousboe,
Alfredo Cagnotto,
Elena Fumagalli, and
Tiziana Mennini
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4505-4508
Design, Synthesis and Biological Evaluation of Novel Arachidonic Acid Derivatives as Highly Potent and Selective Endocannabinoid Transporter Inhibitors
María L. López-Rodríguez,
Alma Viso,
Silvia Ortega-Gutiérrez,
Isabel Lastres-Becker,
Sara González,
Javier Fernández-Ruiz, and
José A. Ramos
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4509-4523
Quadruplex-Interactive Agents as Telomerase Inhibitors: Synthesis of Porphyrins and Structure-Activity Relationship for the Inhibition of Telomerase
Dong-Fang Shi,
Richard T. Wheelhouse,
Daekyu Sun, and
Laurence H. Hurley
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4524-4534
Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B through Structure-Based Drug Design
Paul D. Greenspan,
Kirk L. Clark,
Ruben A. Tommasi,
Scott D. Cowen,
Leslie W. McQuire,
David L. Farley,
John H. van Duzer,
Ronald L. Goldberg,
Huanghai Zhou,
Zhengming Du,
John J. Fitt,
David E. Coppa,
Zheng Fang,
William Macchia,
Lijuan Zhu,
Michael P. Capparelli,
Robert Goldstein,
Andrew M. Wigg,
John R. Doughty,
Regine S. Bohacek, and
Ania K. Knap
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4535-4553
Synthetic 2-Aroylindole Derivatives as a New Class of Potent Tubulin-Inhibitory, Antimitotic Agents
Siavosh Mahboobi,
Herwig Pongratz,
Harald Hufsky,
Jörg Hockemeyer,
Markus Frieser,
Alexei Lyssenko,
Dietrich H. Paper,
Jutta Bürgermeister,
Frank-D. Böhmer,
Heinz-Herbert Fiebig,
Angelika M. Burger,
Silke Baasner, and
Thomas Beckers
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4554-4562
Synthesis, Biological Evaluation, and Pharmacophore Generation of Uracil, 4(3H)-Pyrimidinone, and Uridine Derivatives as Potent and Selective Inhibitors of Parainfluenza 1 (Sendai) Virus
Raffaele Saladino,
Claudia Crestini,
Anna Teresa Palamara,
Maria Chiara Danti,
Fabrizio Manetti,
Federico Corelli,
E. Garaci, and
Maurizio Botta
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4563-4576
Design, Synthesis, and Biological Characterization of Bivalent 1-Methyl-1,2,5,6-tetrahydropyridyl-1,2,5-thiadiazole Derivatives as Selective Muscarinic Agonists
W. G. Rajeswaran,
Yang Cao,
Xi-Ping Huang,
Mary Elizabeth Wroblewski,
Tracy Colclough,
Selina Lee,
Fenghua Liu,
Peter I. Nagy,
James Ellis,
Beth A. Levine,
Karl H. Nocka, and
William S. Messer, Jr.
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4577-4583
Synthesis and Antitumor Activity of Novel C-7 Paclitaxel Ethers: Discovery of BMS-184476
Thomas J. Altstadt,
Craig R. Fairchild,
Jerzy Golik,
Kathy A. Johnston,
John F. Kadow,
Francis Y. Lee,
Byron H. Long,
William C. Rose,
Dolatrai M. Vyas,
Henry Wong,
Mu-Jen Wu, and
Mark D. Wittman
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4584-4594
Structure of Protein Tyrosine Phosphatase 1B in Complex with Inhibitors Bearing Two Phosphotyrosine Mimetics
Zongchao Jia,
Qilu Ye,
A. Nicole Dinaut,
Qingping Wang,
Deena Waddleton,
Paul Payette,
Chidambaram Ramachandran,
Brian Kennedy,
Gabriel Hum, and
Scott D. Taylor
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4595-4614
Dimerization of G-Protein-Coupled Receptors
Mark K. Dean,
Christopher Higgs,
Richard E. Smith,
Robert P. Bywater,
Christopher R. Snell,
Paul D. Scott,
Graham J. G. Upton,
Trevor J. Howe, and
Christopher A. Reynolds
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4615-4627
Structure-Based Generation of a New Class of Potent Cdk4 Inhibitors: New de Novo Design Strategy and Library Design
Teruki Honma,
Kyoko Hayashi,
Tetsuya Aoyama,
Noriaki Hashimoto,
Takumitsu Machida,
Kazuhiro Fukasawa,
Toshiharu Iwama,
Chinatsu Ikeura,
Mari Ikuta,
Ikuko Suzuki-Takahashi,
Yoshikazu Iwasawa,
Takashi Hayama,
Susumu Nishimura, and
Hajime Morishima
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4628-4640
A Novel Approach for the Development of Selective Cdk4 Inhibitors: Library Design Based on Locations of Cdk4 Specific Amino Acid Residues
Teruki Honma,
Takashi Yoshizumi,
Noriaki Hashimoto,
Kyoko Hayashi,
Nobuhiko Kawanishi,
Kazuhiro Fukasawa,
Tohru Takaki,
Chinatsu Ikeura,
Mari Ikuta,
Ikuko Suzuki-Takahashi,
Takashi Hayama,
Susumu Nishimura, and
Hajime Morishima
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4641-4649
Oxindole Derivatives as Orally Active Potent Growth Hormone Secretagogues
Teruhisa Tokunaga,
W. Ewan Hume,
Takashi Umezome,
Kazuhiko Okazaki,
Yasuyuki Ueki,
Kazuo Kumagai,
Shinji Hourai,
Jun Nagamine,
Hitoshi Seki,
Mutsuo Taiji,
Hiroshi Noguchi, and
Ryu Nagata
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4650-4660
Structural Basis for the Binding Affinity of Xanthines with the DNA Intercalator Acridine Orange
Mark B. Lyles,
Ivan L. Cameron, and
H. Ralph Rawls
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4661-4667
Mononuclear Platinum(II) Complex with 2-Phenylpyridine Ligands Showing High Cytotoxicity against Mouse Sarcoma 180 Cells Acquiring High Cisplatin Resistance
Tomoko Okada,
Ibrahim M. El-Mehasseb,
Masato Kodaka,
Takenori Tomohiro,
Ken-ichi Okamoto, and
Hiroaki Okuno
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4668-4676
Chemosensitization of a Multidrug-Resistant Leishmania tropica Line by New Sesquiterpenes from Maytenus magellanica and Maytenus chubutensis
María L. Kennedy,
Fernando Cortés-Selva,
José M. Pérez-Victoria,
Ignacio A. Jiménez,
Antonio G. González,
Orlando M. Muñoz,
Francisco Gamarro,
Santiago Castanys, and
Angel G. Ravelo
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4677-4687
Diaminoindanes as Microsomal Triglyceride Transfer Protein Inhibitors
Gary M. Ksander,
Reynalda deJesus,
Andrew Yuan,
Cynthia Fink,
Michael Moskal,
Eric Carlson,
Paivi Kukkola,
Natalie Bilci,
Eli Wallace,
Alan Neubert,
David Feldman,
Therese Mogelesky,
Kevin Poirier,
Michael Jeune,
Ronald Steele,
Jong Wasvery,
Zouhair Stephan,
Edna Cahill,
Randy Webb,
Aida Navarrete,
Warren Lee,
Joyce Gibson,
Natalya Alexander,
Haamid Sharif, and
Ashok Hospattankar
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4688-4695
C-16 Artemisinin Derivatives and Their Antimalarial and Cytotoxic Activities: Syntheses of Artemisinin Monomers, Dimers, Trimers, and Tetramers by Nucleophilic Additions to Artemisitene
Sanchai Ekthawatchai,
Sumalee Kamchonwongpaisan,
Palangpon Kongsaeree,
Bongkoch Tarnchompoo,
Yodhathai Thebtaranonth, and
Yongyuth Yuthavong
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4696-4703
Design, Synthesis, and Pharmacological Evaluation of Thapsigargin Analogues for Targeting Apoptosis to Prostatic Cancer Cells
Carsten M. Jakobsen,
Samuel R. Denmeade,
John T. Isaacs,
Alyssa Gady,
Carl E. Olsen, and
S ren Brgger Christensen
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4704-4715
2-(2-Piperidyl)- and 2-(2-Pyrrolidyl)chromans as Nicotine Agonists: Synthesis and Preliminary Pharmacological Characterization
Simon M. N. Efange,
Zhude Tu,
Krystyna von Hohenberg,
Lynn Francesconi,
Robertha C. Howell,
Marilyn V. Rampersad,
Louis J. Todaro,
Roger L. Papke, and
Mei-Ping Kung
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4716-4732
Dopamine D3 Receptor Antagonists. 1. Synthesis and Structure-Activity Relationships of 5,6-Dimethoxy-N-alkyl- and N-Alkylaryl-Substituted 2-Aminoindans
Susanne R. Haadsma-Svensson,
Kerry A. Cleek,
Dac M. Dinh,
J. Neil Duncan,
Christopher L. Haber,
Rita M. Huff,
Mary E. Lajiness,
Nanette F. Nichols,
Martin W. Smith,
Kjell A. Svensson,
Matt J. Zaya,
Arvid Carlsson, and
Chiu-Hong Lin
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4733-4736
Synthesis, in Vitro Pharmacology, and Molecular Modeling of syn-Huprines as Acetylcholinesterase Inhibitors
Pelayo Camps,
Elena Gómez,
Diego Muñoz-Torrero,
Albert Badia,
Nuria María Vivas,
Xavier Barril,
Modesto Orozco, and
Francisco Javier Luque
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4737-4740
Design and Synthesis of Non-peptidic Inhibitors for the Syk C-Terminal SH2 Domain Based on Structure-Based In-Silico Screening
Tatsuya Niimi,
Masaya Orita,
Miwa Okazawa-Igarashi,
Hitoshi Sakashita,
Kazumi Kikuchi,
Evelyn Ball,
Atsushi Ichikawa,
Yoko Yamagiwa,
Shuichi Sakamoto,
Akihiro Tanaka,
Shinichi Tsukamoto, and
Shigeo Fujita
, Kuniaki Tatsuta,
Yasuhide Maeda, and
Ken Chikauchi
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4741-4741
| Principles and Applications of Asymmetric Synthesis By Guo-Qiang Lin, Yue-Ming Li, and Albert S. C. Chan. Wiley Interscience, New York. 2001. xvii + 515 pp. 16 × 24 cm. ISBN 0-471-40027-0. $89.95.
Jeffrey Aubé
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4741-4742
| Synthesis and Applications of Isotopically Labelled Compounds. Volume 7. Proceedings of the Seventh International Symposium, Dresden, Germany, June 18-22, 2000 Edited by U. Pleiss and R. Voges. Wiley, New York. 2001. xxv + 702 pp. 17 × 25 cm. ISBN 0-471-49501-8. $220.00.
Crist N. Filer
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